Minetta Creek was one of the largest natural watercourses in Manhattan, New York City, United States. Minetta Creek was fed from two tributaries, one originating at Fifth Avenue and 21st Street, and the other originating at Sixth Avenue and 16th Street. They joined near Fifth Avenue and 11th Street then took a southwesterly course. Minetta Creek's name is thought to have originated from either the Native American term "Manette", meaning "Devil's Water", or the Dutch word "Minnetje", meaning "the little one".