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About: List of phenyltropanes     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatRTICompounds, within Data Space : dbpedia.org:8891 associated with source document(s)

Type: yago:Abstraction100002137yago:Cognition100023271yago:Compound105870180yago:Concept105835747yago:Content105809192yago:Idea105833840yago:PsychologicalFeature100023100yago:Whole105869584yago:WikicatRTICompounds New Facet based on Instances of this Class

Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine. The main feature differentiating phenyltropanes from cocaine is that they lack the ester functionality at the 3-position terminating in the benzene; and thusly the phenyl is attached direct to the tropane skeleton with no further (therefore the name "phenyl"-tropane) that the cocaine benzoyloxy provided. The original purpose of which was to extirpate the cardiotoxicity inherent in the local anesthetic "numbing" capability of cocaine (since the methylated benzoate ester is essential to cocaine's blockage of sodium channels which cause topical anesthesia) while retaining stimulant function. These compounds present many different avenues of research into therapeutic application