Otto Karl Wiesenburg (August 1, 1911 – June 18, 1990) was an American legislator, lawyer, and public servant. He was a member of the Mississippi House of Representatives from 1956 to 1964 and held various other roles in public service for Pascagoula and Jackson County, Mississippi. Wiesenburg is best known for his opposition to Mississippi Governor Ross Barnett's attempt to deny the enrollment of James Meredith into the University of Mississippi.