Howard David Krein (born 1966/1967) is an American otolaryngologist, plastic surgeon, and business executive. He is the husband of Ashley Biden, the daughter of United States President Joe Biden. He is an assistant professor of otolaryngology at Thomas Jefferson University and is a founding partner and co-director of Thomas Jefferson University Hospital's Facial Aesthetic and Reconstructive Center. Krein is the chief medical officer at StartUp Health, a venture capital and health technology firm. He served on the Biden Cancer Initiative's board of directors from 2017 to 2019. Krein has advised the Joe Biden 2020 presidential campaign on its COVID-19 pandemic response in an unofficial role.