Henry Cook Mumbrue (February 15, 1828 – April 8, 1898) was an American steamboat operator, businessman, and Wisconsin pioneer. He served in the Wisconsin State Senate (1877–1878) and Assembly (1876), representing Waupaca County. He was at one point the richest resident of Waupaca County, but his riverboat business was wiped out when train lines arrived in the region. His name is often abbreviated as H. C. Mumbrue.