State Route 125 (SR 125) is a state highway in the U.S. state of California that serves as a north–south freeway in the San Diego area. It runs from SR 11 and SR 905 in Otay Mesa, near the Mexican border, to SR 52 in Santee. SR 125 also connects SR 54, SR 94, and I-8. The definition of the SR 125 route continues to SR 56, but this portion has not been constructed, and there are no plans to do so.