Bryan Station (also Bryan's Station, and often misspelled Bryant's Station) was an early fortified settlement in Lexington, Kentucky. It was located on present-day Bryan Station Road, about three miles (5 km) northeast of New Circle Road, on the southern bank of Elkhorn Creek near Briar Hill Road. The settlement was established circa 1775–76 by brothers Morgan, James, William (married to Mary Boone, sister of Daniel Boone), and Joseph Bryan, and brother-in-law William Grant (married to Elizabeth Boone, also a sister of Daniel Boone), all from Yadkin River Valley, Rowan County, North Carolina, to which all the survivors returned in August 1780. The occupants of this parallelogram of some forty log cabins withstood several American Indian attacks.