Anjette Lyles (née Donovan; August 23, 1925 – December 4, 1977) was an American restauranteur and serial killer responsible for the poisoning deaths of four relatives in Macon, Georgia, between 1952 and 1958. Initially sentenced to death upon her conviction, Lyles was eventually diagnosed with paranoid schizophrenia and instead sent to the Central State Hospital in Milledgeville, where she spent the rest of her life.