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Affilins are artificial proteins designed to selectively bind antigens. Affilin proteins are structurally derived from human ubiquitin (historically also from gamma-B crystallin). Affilin proteins are constructed by modification of surface-exposed amino acids of these proteins and isolated by display techniques such as phage display and screening. They resemble antibodies in their affinity and specificity to antigens but not in structure, which makes them a type of antibody mimetic. Affilin was developed by Scil Proteins GmbH as potential new biopharmaceutical drugs, diagnostics and affinity ligands.

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  • Affilin (de)
  • Affilin (en)
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  • Ein Affilin ist ein künstliches Protein, das zur Bindung von Antigenen befähigt ist. Affiline sind strukturell vom menschlichen Ubiquitin oder von menschlichen abgeleitet. Sie werden durch Veränderung ihrer oberflächennahen Aminosäuren gewonnen und mit Hilfe sogenannter Displaytechniken isoliert. Affiline besitzen sowohl Eigenschaften von Antikörpern als auch die von niedermolekularen Substanzen und werden daher als Antikörpermimetika bezeichnet. Affiline werden derzeit als mögliche neuartige biopharmazeutische Arzneistoffe untersucht und entwickelt. (de)
  • Affilins are artificial proteins designed to selectively bind antigens. Affilin proteins are structurally derived from human ubiquitin (historically also from gamma-B crystallin). Affilin proteins are constructed by modification of surface-exposed amino acids of these proteins and isolated by display techniques such as phage display and screening. They resemble antibodies in their affinity and specificity to antigens but not in structure, which makes them a type of antibody mimetic. Affilin was developed by Scil Proteins GmbH as potential new biopharmaceutical drugs, diagnostics and affinity ligands. (en)
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  • Ein Affilin ist ein künstliches Protein, das zur Bindung von Antigenen befähigt ist. Affiline sind strukturell vom menschlichen Ubiquitin oder von menschlichen abgeleitet. Sie werden durch Veränderung ihrer oberflächennahen Aminosäuren gewonnen und mit Hilfe sogenannter Displaytechniken isoliert. Affiline besitzen sowohl Eigenschaften von Antikörpern als auch die von niedermolekularen Substanzen und werden daher als Antikörpermimetika bezeichnet. Affiline werden derzeit als mögliche neuartige biopharmazeutische Arzneistoffe untersucht und entwickelt. (de)
  • Affilins are artificial proteins designed to selectively bind antigens. Affilin proteins are structurally derived from human ubiquitin (historically also from gamma-B crystallin). Affilin proteins are constructed by modification of surface-exposed amino acids of these proteins and isolated by display techniques such as phage display and screening. They resemble antibodies in their affinity and specificity to antigens but not in structure, which makes them a type of antibody mimetic. Affilin was developed by Scil Proteins GmbH as potential new biopharmaceutical drugs, diagnostics and affinity ligands. (en)
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