The 2022 Charlotte Edwards Cup was the second edition of the Charlotte Edwards Cup, an English women's cricket Twenty20 domestic competition, which took place between 14 May and 11 June 2022. It featured eight teams playing in two double round-robin groups, followed by a Finals Day. The tournament ran alongside the Rachael Heyhoe Flint Trophy. The tournament was named after former England captain Charlotte Edwards. The tournament was won by Southern Vipers, beating Central Sparks in the final.