2021–22 Iran Football's 2nd Division is the 21st under 2nd Division since its establishment (current format) in 2001. The season featured 21 teams from the , three new team relegated from the 2020–21 Azadegan League: Chooka Talesh, Navad Urmia, Gol Reyhan Alborz, and four new teams promoted from the 3rd Division 2020–21: Shahrdari Noshahr, Shahid Oraki Eslamshahr, Van Pars Naghsh-e-Jahan, Shohadaye Razakan Karaj. The draw for the league was held on 26 October 2021.These changes has been applied before the season: