The 2021–22 Colorado State Rams men's basketball team represented Colorado State University for the 2021–22 NCAA Division I men's basketball season. The team was coached by Niko Medved, who was in his fourth season as head coach. The Rams played their home games at Moby Arena on CSU's main campus in Fort Collins, Colorado as members of the Mountain West Conference. They finished the season 25–6, 14–4 in Mountain West Play to finish in second place. As the No. 2 seed, they defeated Utah State in the quarterfinals of the Mountain West tournament before losing in the semifinals to San Diego State. They received an at-large bid to the NCAA tournament as the No. 6 seed in the South Region, where they were upset in the first round by Michigan.