The 2018–19 SMU Mustangs women's basketball team will represent Southern Methodist University in the 2018–19 NCAA Division I women's basketball season. The Mustangs, led by third year head coach Travis Mays, play their home games at Moody Coliseum and were sixth year members of the American Athletic Conference. They finished the season 11–19, 5–11 in AAC play to finish in a 4 way tie for ninth place. They lost in first round of the American Athletic women's tournament to East Carolina.