The 2018–19 Quaid-e-Azam Trophy was a first-class domestic cricket competition that took place in Pakistan from 1 September to 8 December 2018. Following the conclusion of each match, the teams played each other in a List A fixture in the 2018–19 Quaid-e-Azam One Day Cup tournament. Sui Northern Gas Pipelines Limited were the defending champions. In April 2018, Zarai Taraqiati Bank Limited (ZTBL) won the Patron's Trophy Grade-II tournament to qualify for this years' edition of the competition. ZTBL won their opening fixture of the Quaid-e-Azam Trophy, against Lahore Blues, by 151 runs.