U.S. Città di Palermo played the 2011–12 season in Serie A, the eighth consecutive season for the Sicilian club in the Italian top flight since their return to the league in 2004. The club ended the season in 16th place, the worst result in all of its last eight Serie A seasons. The Sicilian club took part in two cup competitions, the UEFA Europa League and the Coppa Italia, being eliminated immediately in both of them.