The 2010 Mid-American Conference football season was the 65th season for the Mid-American Conference (MAC). The season began on Thursday, September 2, with five games: Ball State hosted Southeast Missouri State, Central Michigan hosted Hampton, Kent State hosted Murray State, Buffalo hosted Rhode Island, and Northern Illinois traveled to Ames, Iowa to face Iowa State. The conference's other eight teams began their respective 2010 seasons of NCAA Division I FBS (Football Bowl Subdivision) competition on Friday, September 3, and Saturday, September 4. The first in-conference game was September 9, with Temple hosting Central Michigan.