The 2001 USC Trojans football team represented the University of Southern California in the 2001 NCAA Division I-A football season. It was Pete Carroll's first year as head coach. The Kansas State Wildcats's victory on September 8 marked the last time a non-Pac-10 team defeated the Trojans in the Coliseum until November 27, 2010, when the Notre Dame Fighting Irish defeated the Trojans, 20–16.