The 1st Louisiana Infantry Regiment was a unit of volunteers recruited in Louisiana that fought in the Confederate States Army during the American Civil War. Formed in April 1861, the regiment was sent to fight in the Eastern Theater of the American Civil War. Joining a brigade of Louisiana regiments, it fought at Malvern Hill, Second Bull Run, Antietam, and Fredericksburg in 1862, at Chancellorsville, Second Winchester, Gettysburg, and Mine Run in 1863, and at the Wilderness, Spotsylvania, Monocacy, Third Winchester, Fisher's Hill, Cedar Creek, and Petersburg in 1864, and at Appomattox in 1865. At Appomattox, the regiment was only a shadow of its former self.