The 1992–93 Southern Illinois Salukis men's basketball team represented Southern Illinois University Carbondale during the 1992–93 NCAA Division I men's basketball season. The Salukis were led by fourth-year head coach Bruce Weber and played their home games at the SIU Arena in Carbondale, Illinois as members of the Missouri Valley Conference. They finished the season 23–10, 12–6 in MVC play to finish in second place. The Salukis won the MVC tournament to received an automatic bid to the NCAA tournament as No. 14 seed in the Midwest region. The Salukis fell to two-time defending champion and No. 3 seed Duke in the opening round.