USS Goldsborough (DD-188/AVP-18/AVD-5/APD-32) was a Clemson-class destroyer in the United States Navy during World War II. She was the second Navy ship named for Rear Admiral Louis M. Goldsborough (1805–1877). Entering service in 1920, the ship had a brief active life before being placed in reserve in 1922. Goldsborough was reactivated for World War II and was used as an aircraft tender, destroyer and high speed transport in both Atlantic and Pacific theaters. Following the war, the ship was sold for scrapping in 1946.