The 2021 Charlotte Edwards Cup, initially named the 2021 Women's Regional T20, was the first edition of the Charlotte Edwards Cup, an English women's cricket Twenty20 domestic competition took place between 26 June and 5 September 2021. It featured eight teams playing in two double round-robin groups, followed by a . South East Stars won the tournament, beating Northern Diamonds in the final. The tournament ran alongside the Rachael Heyhoe Flint Trophy.