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Subject Item
dbr:Laudanosine
rdf:type
yago:WikicatNaturalOpiumAlkaloids yago:Alkaloid114712692 yago:Part113809207 yago:Substance100019613 yago:Abstraction100002137 dbo:ChemicalSubstance dbo:ChemicalCompound yago:Matter100020827 yago:Element114840755 yago:OrganicCompound114727670 yago:Quintessence114847103 umbel-rc:ChemicalSubstanceType n15:ChemicalObject wikidata:Q11173 yago:Relation100031921 owl:Thing yago:Material114580897 yago:WikicatPhenolEthers yago:PhysicalEntity100001930 yago:Compound114818238 yago:Chemical114806838 yago:WikicatAlkaloids
rdfs:label
Laudanosine Laudanosina Laudanosin
rdfs:comment
Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. La laudanosina es un alcaloide benciltetrahidroisoquinolínico del opio. La laudanosina disminuye el umbral de convulsiones, por lo que puede inducir convulsiones si están presentes en concentraciones suficientes de umbral. Fue aislado por primera vez en 1871. LA hidrogenación parcial de la laudanosina produce la papaverina. Se ha encontrado que este alcaloide interactúa con los receptores GABA, receptores opioidesy receptores nicotínicospero no a los receptores muscarínicos o benzodiazepinergic cuales están involucrados también en la epilepsia y otros tipos de convulsiones. Laudanosin ist ein giftiges Benzylisochinolin-Alkaloid, das in kleinen Mengen im Schlafmohn vorkommt und strukturell mit Papaverin verwandt ist (N-Methyl-tetrahydropapaverin). Weiterhin ist es ein potentiell toxisches Abbauprodukt der Muskelrelaxanzien Atracurium und (in geringerem Ausmaß) Cisatracurium.
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yago-res:Laudanosine wikidata:Q408074 n21:03g_k_5 dbpedia-es:Laudanosina dbpedia-de:Laudanosin dbpedia-wikidata:Q408074
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dbc:Phenol_ethers dbc:Tetrahydroisoquinolines dbc:Nicotinic_antagonists dbc:GABAA_receptor_negative_allosteric_modulators dbc:Glycine_receptor_antagonists dbc:Convulsants dbc:Natural_opium_alkaloids
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14863278
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744466931
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dbr:Cisatracurium dbr:Dehydration_reaction dbc:Nicotinic_antagonists n12:jpg dbr:Glycine_receptor dbr:Papaverine dbr:Muscarinic_receptor dbr:Opioid_receptor dbr:GABA_receptor dbr:Alkaloid dbr:Nicotinic_acetylcholine_receptor dbc:GABAA_receptor_negative_allosteric_modulators dbr:Benzyltetrahydroisoquinoline dbc:Glycine_receptor_antagonists dbr:Benzodiazepine_receptor dbc:Convulsants dbr:Atracurium dbc:Natural_opium_alkaloids dbc:Phenol_ethers dbr:Opium dbc:Tetrahydroisoquinolines
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wikipedia-en:Laudanosine
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dbo:abstract
La laudanosina es un alcaloide benciltetrahidroisoquinolínico del opio. La laudanosina disminuye el umbral de convulsiones, por lo que puede inducir convulsiones si están presentes en concentraciones suficientes de umbral. Fue aislado por primera vez en 1871. LA hidrogenación parcial de la laudanosina produce la papaverina. Se ha encontrado que este alcaloide interactúa con los receptores GABA, receptores opioidesy receptores nicotínicospero no a los receptores muscarínicos o benzodiazepinergic cuales están involucrados también en la epilepsia y otros tipos de convulsiones. Laudanosin ist ein giftiges Benzylisochinolin-Alkaloid, das in kleinen Mengen im Schlafmohn vorkommt und strukturell mit Papaverin verwandt ist (N-Methyl-tetrahydropapaverin). Weiterhin ist es ein potentiell toxisches Abbauprodukt der Muskelrelaxanzien Atracurium und (in geringerem Ausmaß) Cisatracurium. Laudanosin durchdringt die Blut-Hirn-Schranke und wirkt über Interaktionen mit GABA-, Opioid- und nikotinischen Acetylcholinrezeptoren epileptogen, d. h. cerebral erregend. Es kann im Herz-Kreislaufsystem zu Blutdruckabfall (Hypotonie) und verlangsamtem Herzschlag (Bradykardie) führen. In der Praxis spielen die Wirkungen von Laudanosin bei den üblichen Dosierungen der Muskelrelaxanzien in der Regel allerdings keine Rolle. Es erhöht weiterhin den MAC-Wert der verwendeten volatilen Narkotika bei einer Narkose. Laudanosin wird renal ausgeschieden. Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. Laudanosine also occurs naturally in minute amounts (0.1%) in opium, from which it was first isolated in 1871. Partial dehydrogenation of laudanosine will lead to papaverine, the alkaloid found in the opium poppy plant (Papaver somniferum). Laudanosine is a benzyltetrahydroisoquinoline alkaloid. It has been shown to interact with GABA receptors, glycine receptors, opioid receptors, and nicotinic acetylcholine receptors, but not benzodiazepine or muscarinic receptors which are also involved in epilepsy and other types of seizures.
dbo:iupacName
(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy- 2-methyl-3,4-dihydro-1H-isoquinoline
dbp:imagefile
Laudanosine molecule spacefill.png Laudanosine.svg
dbp:imagename
Space-filling model Skeletal formula
dbp:imagesize
220 180
dbp:othernames
N-Methyl-1,2,3,4-tetrahydropapaverine
dbp:verifiedfields
changed
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424953216
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changed
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