"5812801"^^ . . . . . "\u03B21"@en . . "1113032304"^^ . . . . "HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen \u2013 DR isotype) and peptide, generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease. Identification of these antigens has led to greater success and longevity in organ transplant."@en . . . . . "antigen presentation"@en . . . "\u03B1"@en . "\u03B23"@en . "MHC class II, DR"@en . . . . . . . . . . . . . . . . "Illustration of DR with bound ligand"@en . . . . . "\u03B25"@en . . . . . . . . . "\" \""@en . . . . . . . . "\u03B24"@en . . "Immune recognition and"@en . "5"^^ . . . . . . . . . . . . . . . . "31093"^^ . "heterodimer"@en . . . . . . . . . . . . . . . . . . . . "HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen \u2013 DR isotype) and peptide, generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease. Identification of these antigens has led to greater success and longevity in organ transplant. Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival). Good matching of these antigens between host and donor is most critical for achieving graft survival. HLA-DR is also involved in several autoimmune conditions, disease susceptibility and disease resistance. It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease. HLA-DR molecules are upregulated in response to signalling. In the instance of an infection, the peptide (such as the staphylococcal enterotoxin I peptide) is bound into a DR molecule and presented to a few of a great many T-cell receptors found on T-helper cells. These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation."@en . . . . . . . . . . "HLA-DR"@en . . . . . . "Chromosome 6p21.31"@en . . . .