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Statements

Subject Item
dbr:Dihydroceramide_desaturase
rdf:type
yago:Molecule114682133 yago:Unit109465459 wikidata:Q206229 yago:Compound114818238 dbo:Biomolecule yago:WikicatEnzymes yago:Thing100002452 yago:Chemical114806838 yago:Activator114723079 yago:Matter100020827 yago:Material114580897 yago:Abstraction100002137 yago:Enzyme114732946 owl:Thing yago:Part113809207 yago:Macromolecule114944888 dbo:Enzyme yago:PhysicalEntity100001930 dbo:Protein yago:OrganicCompound114727670 wikidata:Q8047 yago:Substance100019613 yago:Relation100031921 yago:Catalyst114723628 yago:Protein114728724
rdfs:label
Dihydroceramide desaturase
rdfs:comment
Dihydroceramide desaturase is the enzyme involved in the conversion of into ceramide by inserting the 4,5-trans-double bond to the sphingolipid backbone of dihydroceramide. DDase require the O2 and the NAD(P)H as cofactor. The activity of DDase is influenced by several factors as N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), is the inhibitor DDase activity.
foaf:name
Dihydroceramide desaturase
dbp:name
Dihydroceramide desaturase
dcterms:subject
dbc:Enzymes
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1048023725
dbo:wikiPageWikiLink
dbc:Enzymes dbr:Biological_reductant dbr:Stereochemistry dbr:Dihydroceramide dbr:Ceramide dbr:NAD(P)H dbr:Enzyme dbr:Sphingolipid
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dbo:abstract
Dihydroceramide desaturase is the enzyme involved in the conversion of into ceramide by inserting the 4,5-trans-double bond to the sphingolipid backbone of dihydroceramide. DDase require the O2 and the NAD(P)H as cofactor. The activity of DDase is influenced by several factors as 1. * alkyl chain length of the sphingoid base (in the order C18 > C12 > C8) and fatty acid (C8 > C18) 2. * The stereochemistry of the sphingoid base (D-erythro- > L-threo-dihydroceramides) 3. * the nature of the headgroup, with the highest activity with dihydroceramide, but some (approximately 20%) activity with dihydroglucosylceramide 4. * The ability to utilize alternative reductants like ascorbic acid could substitute for a reduced pyridine nucleotide, but it act as inhibitory at higher concentrations. N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), is the inhibitor DDase activity.
gold:hypernym
dbr:Enzyme
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wikipedia-en:Dihydroceramide_desaturase?oldid=1048023725&ns=0
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