. . . . "146441"^^ . . . . "1121778762"^^ . . . . . . . . . . . . . . . . . "179978"^^ . . . . . . . "Antyandrogeny \u2013 zwi\u0105zki chemiczne zmniejszaj\u0105ce oddzia\u0142ywanie androgen\u00F3w na organizm, stosowane np. w przedwczesnym pokwitaniu (dojrzewaniu) oraz leczeniu raka gruczo\u0142u krokowego (prostaty)."@pl . . . . "\u0410\u043D\u0442\u0438\u0430\u043D\u0434\u0440\u043E\u0433\u0435\u0301\u043D\u044B \u2014 \u0433\u0440\u0443\u043F\u043F\u0430 \u0433\u043E\u0440\u043C\u043E\u043D\u0430\u043B\u044C\u043D\u044B\u0445 \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u043E\u0432, \u044F\u0432\u043B\u044F\u044E\u0449\u0438\u0445\u0441\u044F \u0430\u043D\u0442\u0430\u0433\u043E\u043D\u0438\u0441\u0442\u0430\u043C\u0438 \u0430\u043D\u0434\u0440\u043E\u0433\u0435\u043D\u043E\u0432. \u041F\u0440\u0438\u043C\u0435\u043D\u044F\u044E\u0442\u0441\u044F \u0443 \u0436\u0435\u043D\u0449\u0438\u043D \u2014 \u043F\u0440\u0438 \u0432\u044B\u0440\u0430\u0436\u0435\u043D\u043D\u044B\u0445 \u044F\u0432\u043B\u0435\u043D\u0438\u044F\u0445 \u0430\u043D\u0434\u0440\u043E\u0433\u0435\u043D\u0438\u0437\u0430\u0446\u0438\u0438 (\u0447\u0440\u0435\u0437\u043C\u0435\u0440\u043D\u043E\u0435 \u043E\u0432\u043E\u043B\u043E\u0441\u0435\u043D\u0438\u0435, \u0441\u0435\u0431\u043E\u0440\u0435\u044F, \u0443\u0433\u0440\u0438); \u0432 \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0444\u0435\u043C\u0438\u043D\u0438\u0437\u0438\u0440\u0443\u044E\u0449\u0435\u0439 \u0433\u043E\u0440\u043C\u043E\u043D\u0430\u043B\u044C\u043D\u043E\u0439 \u0442\u0435\u0440\u0430\u043F\u0438\u0438 \u0443 \u0442\u0440\u0430\u043D\u0441-\u0436\u0435\u043D\u0449\u0438\u043D; \u0443 \u0434\u0435\u0442\u0435\u0439 \u2014 \u043F\u0440\u0438 \u0438\u0434\u0438\u043E\u043F\u0430\u0442\u0438\u0447\u0435\u0441\u043A\u043E\u043C \u043F\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043C\u0435\u043D\u043D\u043E\u043C \u043F\u043E\u043B\u043E\u0432\u043E\u043C \u0441\u043E\u0437\u0440\u0435\u0432\u0430\u043D\u0438\u0438; \u0443 \u043C\u0443\u0436\u0447\u0438\u043D \u2014 \u043F\u0440\u0438 \u0430\u0434\u0435\u043D\u043E\u043C\u0435 \u0438\u043B\u0438 \u0440\u0430\u043A\u0435 \u043F\u0440\u0435\u0434\u0441\u0442\u0430\u0442\u0435\u043B\u044C\u043D\u043E\u0439 \u0436\u0435\u043B\u0435\u0437\u044B (\u0441\u0438\u0441\u0442\u0435\u043C\u043D\u043E) \u0438 \u043F\u0440\u0438 \u043E\u0431\u043B\u044B\u0441\u0435\u043D\u0438\u0438 \u0438 \u043B\u0435\u0447\u0435\u043D\u0438\u0438 \u0443\u0433\u0440\u0435\u0439, \u0441\u0435\u0431\u043E\u0440\u0435\u0438 (\u043C\u0435\u0441\u0442\u043D\u043E)."@ru . . "Un antiandrogeno \u00E8 un gruppo di composti antagonista del recettore dell'ormone in grado di prevenire o inibire gli effetti biologici degli androgeni, ormoni sessuali maschili, sui tessuti sensibili del corpo. Gli antiandrogeni solitamente funzionano bloccando i recettori."@it . "250"^^ . "Antiandr\u00F3genos, tamb\u00E9m conhecidos como antagonistas de andr\u00F3genos ou bloqueadores de testosterona, s\u00E3o uma classe de medicamentos que previne os andr\u00F3genos, como a testosterona e a di-hidrotestosterona(DHT), de mediar seus efeitos biol\u00F3gicos no organismo. Eles agem bloqueando o receptor androg\u00EAnico (RA) e/ou inibindo ou suprimindo a produ\u00E7\u00E3o de andr\u00F3genos. Eles podem ser considerados os opostos funcionais de agonistas de RA por exemplo andr\u00F3genos e ester\u00F3ides anabolizantes (EA) como testosterona, DHT e nandrolona e moduladores seletivos de receptor de androg\u00EAnio (SARMs) como o enobosarma. Antiandrog\u00EAnios s\u00E3o um dos tr\u00EAs tipos de antagonistas de horm\u00F4nios sexuais, sendo os outroso antiestrog\u00EAnios e o antiprogest\u00F3genos. Antiandr\u00F3genos s\u00E3o usados para tratar uma variedade de condi\u00E7\u00F5es dependentes de andr\u00F3genos. Nos homens, os antiandrog\u00EAnicos s\u00E3o usados no tratamento do c\u00E2ncer de pr\u00F3stata, pr\u00F3stata aumentada, perda de cabelo no couro cabeludo, impulso sexual excessivamente alto, impulsos sexuais incomuns e problem\u00E1ticos e puberdade precoce."@pt . . . . . . . "Antyandrogeny \u2013 zwi\u0105zki chemiczne zmniejszaj\u0105ce oddzia\u0142ywanie androgen\u00F3w na organizm, stosowane np. w przedwczesnym pokwitaniu (dojrzewaniu) oraz leczeniu raka gruczo\u0142u krokowego (prostaty)."@pl . . . . . . . . . . . "Les anti-androg\u00E8nes sont des mol\u00E9cules diminuant l'activit\u00E9 des hormones androg\u00E8nes. Ils bloquent les r\u00E9cepteurs aux androg\u00E8nes ou diminuant la synth\u00E8se des androg\u00E8nes."@fr . . . . . . . . . "Antiandrogen"@en . . . . . . . . . . . . . . . . . . . "\u0645\u0636\u0627\u062F\u0627\u062A \u0627\u0644\u0623\u0646\u062F\u0631\u0648\u062C\u064A\u0646 Antiandrogens \u0623\u062F\u062A \u0627\u0644\u0641\u0627\u0626\u062F\u0629 \u0627\u0644\u0645\u062D\u062A\u0645\u0644\u0629 \u0644\u0645\u0636\u0627\u062F\u0627\u062A \u0627\u0644\u0623\u0646\u062F\u0631\u0648\u062C\u064A\u0646 \u0641\u064A \u0645\u0639\u0627\u0644\u062C\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064A\u0646 \u064A\u0646\u062A\u062C\u0648\u0646 \u0643\u0645\u064A\u0627\u062A \u0643\u0628\u064A\u0631\u0629 \u0645\u0646 \u0627\u0644\u062A\u0633\u062A\u0648\u0633\u062A\u0631\u0648\u0646 \u0625\u0644\u0649 \u0627\u0644\u0628\u062D\u062B \u0639\u0646 \u0623\u062F\u0648\u064A\u0629 \u0641\u0639\u0627\u0644\u0629 \u064A\u0645\u0643\u0646\u0647\u0627 \u0623\u0646 \u062A\u0633\u062A\u0639\u0645\u0644 \u0644\u0647\u0630\u0627 \u0627\u0644\u063A\u0631\u0636.\u0647\u0646\u0627\u0644\u0643 \u0639\u062F\u0629 \u0645\u0642\u0627\u0631\u0628\u0627\u062A \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u0634\u0643\u0644\u0629\u060C \u0648\u0646\u062C\u062D \u0645\u0646\u0647\u0627 \u0628\u0627\u0644\u0623\u062E\u0635 \u0645\u0646\u0639 \u0627\u0644\u062A\u0635\u0646\u064A\u0639 \u0648\u062D\u0635\u0631 \u0627\u0644\u0645\u0633\u062A\u0642\u0628\u0644"@ar . . . . . . . . "Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. They act by blocking the androgen receptor (AR) and/or inhibiting or suppressing androgen production. They can be thought of as the functional opposites of AR agonists, for instance androgens and anabolic steroids (AAS) like testosterone, DHT, and nandrolone and selective androgen receptor modulators (SARMs) like enobosarm. Antiandrogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiprogestogens."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "source does not attribute antiandrogen as the causative agent of all side effects listed."@en . . "Un antiandr\u00F3geno o antagonista androg\u00E9nico es un grupo de f\u00E1rmacos que ejercen una acci\u00F3n antagonista o supresi\u00F3n hormonal capaz de prevenir o inhibir los efectos biol\u00F3gicos de los andr\u00F3genos u hormonas sexuales masculinas en las respuestas normales de los tejidos corporales a estas hormonas. Los antiandr\u00F3genos normalmente act\u00FAan bloqueando los receptores androg\u00E9nicos, compitiendo con los sitios de uni\u00F3n en la superficie de las c\u00E9lulas, literalmente obstruyendo la funci\u00F3n de los andr\u00F3genos."@es . . . . . . . . . . . . . . . . . "Antiandrogene sind Arzneistoffe, die die Wirkung der m\u00E4nnlichen Sexualhormone (Androgene) hemmen. Substanzen wie Cyproteronacetat (6-Chlor-1\u03B1,2\u03B1-methylen-17-acetoxy-pregna-4,6-dien-3,20-dion) und Flutamid blockieren Androgenrezeptoren z. B. an der Prostata und heben so die Wirkung von Androgenen auf. Deshalb werden Antiandrogene u. a. bei Prostatakrebs eingesetzt, weil die Androgenwirkung das Tumorwachstum beg\u00FCnstigen w\u00FCrde. M\u00F6gliche Nebenwirkungen sind dabei m\u00E4nnliches Brustwachstum (Gyn\u00E4komastie), Libido- und Potenzverlust. Deshalb k\u00F6nnen Antiandrogene auch im Rahmen einer chemischen Kastration eingesetzt werden. Weitere Pr\u00E4parate: Bicalutamid, Chlormadinon, Drospirenon, Enzalutamid, Abirateron, Spironolacton, Medroxyprogesteron."@de . . . . . . . . . . . . "D000726"@en . . . . . "L02BB"@en . . . . . "Antiandrogene"@de . . . . "\u2022 Men and boys: Prostate cancer; Benign prostatic hyperplasia; Scalp hair loss; Paraphilias; Hypersexuality; Sex offenders; Precocious puberty; Priapism"@en . . . . . . . . . . . . . . . . . "\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u5264(\u3053\u3046\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u3056\u3044\u3001\u82F1\u8A9E:Antiandrogen)\u3068\u306F\u3001\u4EBA\u4F53\u306B\u304A\u3051\u308B\u7537\u6027\u30DB\u30EB\u30E2\u30F3\uFF08\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\uFF09\u306E\u306F\u305F\u3089\u304D\u3092\u6291\u5236\u3059\u308B\u85AC\u7269\u306E\u7DCF\u79F0\u3067\u3042\u308B\u3002\u6297\u7537\u6027\u30DB\u30EB\u30E2\u30F3\u5264\u3068\u3082\u547C\u3070\u308C\u308B\u3002 \u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u526F\u4F5C\u7528\u306F\u3001\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u30BF\u30A4\u30D7\u3068\u7279\u5B9A\u306E\u4F5C\u7528\u306B\u3088\u3063\u3066\u7570\u306A\u308B\u3002\u3044\u305A\u308C\u306B\u305B\u3088\u3001\u7537\u6027\u306B\u304A\u3051\u308B\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u4E00\u822C\u7684\u306A\u526F\u4F5C\u7528\u306B\u306F\u3001\u4E73\u623F\u306E\u5727\u75DB\u3001\u4E73\u623F\u80A5\u5927\u3001\u5973\u6027\u5316\u3001\u307B\u3066\u308A\u3001\u6027\u6A5F\u80FD\u969C\u5BB3\u3001\u4E0D\u598A\u75C7\u3001\u304A\u3088\u3073\u9AA8\u7C97\u9B06\u75C7\u304C\u542B\u307E\u308C\u308B\u3002\u5973\u6027\u306B\u304A\u3044\u3066\u306F\u3001\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u5FCD\u5BB9\u6027\u306F\u306F\u308B\u304B\u306B\u9AD8\u304F\u3001\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u3092\u76F4\u63A5\u30D6\u30ED\u30C3\u30AF\u3059\u308B\u3053\u3068\u306B\u3088\u3063\u3066\u306E\u307F\u6A5F\u80FD\u3059\u308B\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306F\u3001\u6700\u5C0F\u9650\u306E\u526F\u4F5C\u7528\u3092\u3082\u305F\u3089\u3059\u3002\u3057\u304B\u3057\u306A\u304C\u3089\u3001\u30A8\u30B9\u30C8\u30ED\u30B2\u30F3\u306F\u4F53\u5185\u306E\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u304B\u3089\u4F5C\u3089\u308C\u3066\u3044\u308B\u305F\u3081\u3001\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u7523\u751F\u3092\u6291\u5236\u3059\u308B\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306F\u3001\u9589\u7D4C\u524D\u306E\u5973\u6027\u306B\u30A8\u30B9\u30C8\u30ED\u30B2\u30F3\u30EC\u30D9\u30EB\u306E\u4F4E\u4E0B\u3068\u3001\u307B\u3066\u308A\u3001\u6708\u7D4C\u4E0D\u9806\u3001\u9AA8\u7C97\u9B06\u75C7\u306A\u3069\u306E\u95A2\u9023\u75C7\u72B6\u3092\u5F15\u304D\u8D77\u3053\u3059\u53EF\u80FD\u6027\u304C\u3042\u308B\u3002"@ja . . . . . . . . "Androgen antagonists; Androgen blockers; Testosterone blockers"@en . . . . . . . . . . . "\u0645\u0636\u0627\u062F\u0627\u062A \u0627\u0644\u0623\u0646\u062F\u0631\u0648\u062C\u064A\u0646 Antiandrogens \u0623\u062F\u062A \u0627\u0644\u0641\u0627\u0626\u062F\u0629 \u0627\u0644\u0645\u062D\u062A\u0645\u0644\u0629 \u0644\u0645\u0636\u0627\u062F\u0627\u062A \u0627\u0644\u0623\u0646\u062F\u0631\u0648\u062C\u064A\u0646 \u0641\u064A \u0645\u0639\u0627\u0644\u062C\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064A\u0646 \u064A\u0646\u062A\u062C\u0648\u0646 \u0643\u0645\u064A\u0627\u062A \u0643\u0628\u064A\u0631\u0629 \u0645\u0646 \u0627\u0644\u062A\u0633\u062A\u0648\u0633\u062A\u0631\u0648\u0646 \u0625\u0644\u0649 \u0627\u0644\u0628\u062D\u062B \u0639\u0646 \u0623\u062F\u0648\u064A\u0629 \u0641\u0639\u0627\u0644\u0629 \u064A\u0645\u0643\u0646\u0647\u0627 \u0623\u0646 \u062A\u0633\u062A\u0639\u0645\u0644 \u0644\u0647\u0630\u0627 \u0627\u0644\u063A\u0631\u0636.\u0647\u0646\u0627\u0644\u0643 \u0639\u062F\u0629 \u0645\u0642\u0627\u0631\u0628\u0627\u062A \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u0634\u0643\u0644\u0629\u060C \u0648\u0646\u062C\u062D \u0645\u0646\u0647\u0627 \u0628\u0627\u0644\u0623\u062E\u0635 \u0645\u0646\u0639 \u0627\u0644\u062A\u0635\u0646\u064A\u0639 \u0648\u062D\u0635\u0631 \u0627\u0644\u0645\u0633\u062A\u0642\u0628\u0644"@ar . . . . . . . . . . . . . . . . . . . . . . . . "July 2019"@en . . . . . . "Antiandrogeny jsou l\u00E9ky, kter\u00E9 kompetitivn\u011B blokuj\u00ED \u00FA\u010Dinky androgen\u016F na c\u00EDlov\u00E9 org\u00E1ny \u2013 tj. testikul\u00E1rn\u00ED tk\u00E1\u0148 a tk\u00E1\u0148 nadledvin. V\u00FDsledkem je zablokov\u00E1n\u00ED \u00FA\u010Dink\u016F na prostatickou tk\u00E1\u0148, vlasy, mazov\u00E9 \u017El\u00E1zy a CNS. Indikace: \n* L\u00E9\u010Dba u karcinomu prostaty \n* L\u00E9\u010Dba hirzutismu \n* L\u00E9\u010Dba sexu\u00E1ln\u00EDch deviant\u016F \n* Hormon\u00E1ln\u00ED terapie a l\u00E9\u010Dba genderov\u00E9 dysforie u MtF transgender osob V sexuologii se pou\u017E\u00EDv\u00E1 zejm\u00E9na l\u00E9\u010Dba sexu\u00E1ln\u00EDch deviant\u016F. U spolehliv\u00FDch pacient\u016F se l\u00E1tka u\u017E\u00EDv\u00E1 v podob\u011B tablet, u nespolehliv\u00FDch \u010Di odm\u00EDtaj\u00EDc\u00EDch l\u00E9\u010Dbu v podob\u011B depotn\u00EDch prepar\u00E1t\u016F jednou t\u00FDdn\u011B nebo jednou za 14 dn\u00ED. K t\u011Bmto l\u00E9k\u016Fm pat\u0159\u00ED Cyproteron acetat (komer\u010Dn\u00ED n\u00E1zev Androcur), spironolakton (komer\u010Dn\u00ED n\u00E1zvy Aldactone, Spiractin a dal\u0161\u00ED), bicalutamid (komer\u010Dn\u00ED n\u00E1zev Casodex)."@cs . . . . . . . . . . . . . . . . "Un antiandrogen o antagonista androgen \u00E9s aquell f\u00E0rmac que realitza una supressi\u00F3 hormonal capa\u00E7 de prevenir o inhibir els efectes biol\u00F2gics dels andr\u00F2gens o hormones sexuals masculines en les respostes normals dels teixits corporals a aquestes hormones. Els antiandr\u00F2gens actuen normalment blocant els receptors d'andr\u00F2gens, competint d'aquesta manera amb els llocs d'uni\u00F3 a la superf\u00EDcie de les c\u00E8l\u00B7lules, obstruint literalment la funci\u00F3 dels andr\u00F2gens."@ca . . . . "Antiandrogeny"@cs . . . . . . . . . . . . "\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u5264"@ja . . "\u6297\u96C4\u6FC0\u7D20\uFF08anti-androgens\uFF09\uFF0C\u6216\u7A31\u70BA\u96C4\u6027\u6FC0\u7D20\u62EE\u6297\u5291\uFF08androgen antagonists\uFF09\u3002\u65BC1960\u5E74\u4EE3\u6642\u88AB\u767C\u73FE\uFF0C\u85C9\u7531\u963B\u65B7\u7279\u5B9A\u7684\u53D7\u9AD4\u800C\u6291\u5236\u96C4\u6027\u6FC0\u7D20\u7684\u4F5C\u7528\u3002\u53EF\u4EE5\u7AF6\u722D\u7D30\u80DE\u8868\u9762\u7684\u63A5\u53D7\u5668\u6216\u662F\u5F71\u97FF\u96C4\u6027\u6FC0\u7D20\u7684\u7522\u751F\u3002\u6297\u96C4\u6FC0\u7D20\u53EF\u7528\u4F86\u6CBB\u7642\u4E00\u7CFB\u5217\u7684\u75BE\u75C5\u3002\u5728\u7537\u6027\uFF0C\u6297\u96C4\u6FC0\u7D20\u7D93\u5E38\u7528\u4F86\u6CBB\u7642\u524D\u5217\u817A\u764C\u3002\u5BF9\u5973\u6027\u4F7F\u7528\u901A\u5E38\u7528\u4F86\u6E1B\u5C11\u9AD4\u5167\u904E\u591A\u7684\u96C4\u6027\u6FC0\u7D20\u3002\u6297\u96C4\u6FC0\u7D20\u5C0D\u74B0\u5883\u7684\u5F71\u97FF\u5DF2\u7D93\u53D7\u5230\u9AD8\u5EA6\u7684\u95DC\u6CE8\u3002\u8A31\u591A\u7684\u5DE5\u696D\u5316\u5B78\u7269\u8CEA\u3001\u6BBA\u87F2\u5291\u90FD\u6709\u6297\u96C4\u6FC0\u7D20\u7684\u4F5C\u7528\u3002\u4E00\u4E9B\u7279\u5B9A\u7684\u690D\u7269\u4E5F\u88AB\u767C\u73FE\u6703\u7522\u751F\u6297\u96C4\u6FC0\u7D20\u3002\u74B0\u5883\u4E2D\u7684\u6297\u96C4\u6FC0\u7D20\u5C0D\u65BC\u751F\u6B96\u7CFB\u7D71\u9084\u5728\u767C\u80B2\u7684\u5C0F\u5B69\u6703\u6709\u6DF1\u9060\u7684\u5F71\u97FF\u3002"@zh . . . . . "\u0410\u043D\u0442\u0438\u0430\u043D\u0434\u0440\u043E\u0433\u0435\u043D\u044B"@ru . . . . . "Un antiandr\u00F3geno o antagonista androg\u00E9nico es un grupo de f\u00E1rmacos que ejercen una acci\u00F3n antagonista o supresi\u00F3n hormonal capaz de prevenir o inhibir los efectos biol\u00F3gicos de los andr\u00F3genos u hormonas sexuales masculinas en las respuestas normales de los tejidos corporales a estas hormonas. Los antiandr\u00F3genos normalmente act\u00FAan bloqueando los receptores androg\u00E9nicos, compitiendo con los sitios de uni\u00F3n en la superficie de las c\u00E9lulas, literalmente obstruyendo la funci\u00F3n de los andr\u00F3genos."@es . "\u0645\u0636\u0627\u062F\u0627\u062A \u0627\u0644\u0623\u0646\u062F\u0631\u0648\u062C\u064A\u0646"@ar . . . . . . . . "\u2022 Women and girls: Acne; Seborrhea; Hidradenitis suppurativa; Hirsutism; Scalp hair loss; Hyperandrogenism; Transgender hormone therapy"@en . . . . . "Antiandrogene sind Arzneistoffe, die die Wirkung der m\u00E4nnlichen Sexualhormone (Androgene) hemmen. Substanzen wie Cyproteronacetat (6-Chlor-1\u03B1,2\u03B1-methylen-17-acetoxy-pregna-4,6-dien-3,20-dion) und Flutamid blockieren Androgenrezeptoren z. B. an der Prostata und heben so die Wirkung von Androgenen auf. Deshalb werden Antiandrogene u. a. bei Prostatakrebs eingesetzt, weil die Androgenwirkung das Tumorwachstum beg\u00FCnstigen w\u00FCrde. M\u00F6gliche Nebenwirkungen sind dabei m\u00E4nnliches Brustwachstum (Gyn\u00E4komastie), Libido- und Potenzverlust. Deshalb k\u00F6nnen Antiandrogene auch im Rahmen einer chemischen Kastration eingesetzt werden. Weitere Pr\u00E4parate: Bicalutamid, Chlormadinon, Drospirenon, Enzalutamid, Abirateron, Spironolacton, Medroxyprogesteron."@de . . . "Bicalutamide, a nonsteroidal antiandrogen and the most widely used androgen receptor antagonist in the treatment of prostate cancer."@en . . "Antiandr\u00F3geno"@pt . . . . . . "Androgen receptor; Progesterone receptor; Estrogen receptor; receptor; 5\u03B1-Reductase; CYP17A1 ; P450scc; Others"@en . "Un antiandrogeno \u00E8 un gruppo di composti antagonista del recettore dell'ormone in grado di prevenire o inibire gli effetti biologici degli androgeni, ormoni sessuali maschili, sui tessuti sensibili del corpo. Gli antiandrogeni solitamente funzionano bloccando i recettori. Gli antiandrogeni possono essere utilizzati per il trattamento dell'iperplasia prostatica benigna (ingrossamento della prostata), acne, alopecia androgenetica (calvizie maschile), e irsutismo (eccessiva pelosit\u00E0). A volte essi sono utilizzati anche come agente contraccettivo maschile o per reprimere la mascolinizzazione nel caso di una disforia di genere."@it . . "Anti-androg\u00E8ne"@fr . . . . . . . . . "Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. They act by blocking the androgen receptor (AR) and/or inhibiting or suppressing androgen production. They can be thought of as the functional opposites of AR agonists, for instance androgens and anabolic steroids (AAS) like testosterone, DHT, and nandrolone and selective androgen receptor modulators (SARMs) like enobosarm. Antiandrogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiprogestogens. Antiandrogens are used to treat an assortment of androgen-dependent conditions. In men, antiandrogens are used in the treatment of prostate cancer, enlarged prostate, scalp hair loss, overly high sex drive, unusual and problematic sexual urges, and early puberty. In women, antiandrogens are used to treat acne, seborrhea, excessive hair growth, scalp hair loss, and high androgen levels, such as those that occur in polycystic ovary syndrome (PCOS). Antiandrogens are also used as a component of feminizing hormone therapy for transgender women and as puberty blockers in transgender girls. Side effects of antiandrogens depend on the type of antiandrogen and the specific antiandrogen in question. In any case, common side effects of antiandrogens in men include breast tenderness, breast enlargement, feminization, hot flashes, sexual dysfunction, infertility, and osteoporosis. In women, antiandrogens are much better tolerated, and antiandrogens that work only by directly blocking androgens are associated with minimal side effects. However, because estrogens are made from androgens in the body, antiandrogens that suppress androgen production can cause low estrogen levels and associated symptoms like hot flashes, menstrual irregularities, and osteoporosis in premenopausal women. There are a few different major types of antiandrogens. These include AR antagonists, androgen synthesis inhibitors, and antigonadotropins. AR antagonists work by directly blocking the effects of androgens, while androgen synthesis inhibitors and antigonadotropins work by lowering androgen levels. AR antagonists can be further divided into steroidal antiandrogens and nonsteroidal antiandrogens; androgen synthesis inhibitors can be further divided mostly into CYP17A1 inhibitors and 5\u03B1-reductase inhibitors; and antigonadotropins can be further divided into gonadotropin-releasing hormone modulators (GnRH modulators), progestogens, and estrogens."@en . . . . . . . . . . . . "Antiandr\u00F3geno"@es . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "\u0410\u043D\u0442\u0438\u0430\u043D\u0434\u0440\u043E\u0433\u0435\u0301\u043D\u044B \u2014 \u0433\u0440\u0443\u043F\u043F\u0430 \u0433\u043E\u0440\u043C\u043E\u043D\u0430\u043B\u044C\u043D\u044B\u0445 \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u043E\u0432, \u044F\u0432\u043B\u044F\u044E\u0449\u0438\u0445\u0441\u044F \u0430\u043D\u0442\u0430\u0433\u043E\u043D\u0438\u0441\u0442\u0430\u043C\u0438 \u0430\u043D\u0434\u0440\u043E\u0433\u0435\u043D\u043E\u0432. \u041F\u0440\u0438\u043C\u0435\u043D\u044F\u044E\u0442\u0441\u044F \u0443 \u0436\u0435\u043D\u0449\u0438\u043D \u2014 \u043F\u0440\u0438 \u0432\u044B\u0440\u0430\u0436\u0435\u043D\u043D\u044B\u0445 \u044F\u0432\u043B\u0435\u043D\u0438\u044F\u0445 \u0430\u043D\u0434\u0440\u043E\u0433\u0435\u043D\u0438\u0437\u0430\u0446\u0438\u0438 (\u0447\u0440\u0435\u0437\u043C\u0435\u0440\u043D\u043E\u0435 \u043E\u0432\u043E\u043B\u043E\u0441\u0435\u043D\u0438\u0435, \u0441\u0435\u0431\u043E\u0440\u0435\u044F, \u0443\u0433\u0440\u0438); \u0432 \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0444\u0435\u043C\u0438\u043D\u0438\u0437\u0438\u0440\u0443\u044E\u0449\u0435\u0439 \u0433\u043E\u0440\u043C\u043E\u043D\u0430\u043B\u044C\u043D\u043E\u0439 \u0442\u0435\u0440\u0430\u043F\u0438\u0438 \u0443 \u0442\u0440\u0430\u043D\u0441-\u0436\u0435\u043D\u0449\u0438\u043D; \u0443 \u0434\u0435\u0442\u0435\u0439 \u2014 \u043F\u0440\u0438 \u0438\u0434\u0438\u043E\u043F\u0430\u0442\u0438\u0447\u0435\u0441\u043A\u043E\u043C \u043F\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043C\u0435\u043D\u043D\u043E\u043C \u043F\u043E\u043B\u043E\u0432\u043E\u043C \u0441\u043E\u0437\u0440\u0435\u0432\u0430\u043D\u0438\u0438; \u0443 \u043C\u0443\u0436\u0447\u0438\u043D \u2014 \u043F\u0440\u0438 \u0430\u0434\u0435\u043D\u043E\u043C\u0435 \u0438\u043B\u0438 \u0440\u0430\u043A\u0435 \u043F\u0440\u0435\u0434\u0441\u0442\u0430\u0442\u0435\u043B\u044C\u043D\u043E\u0439 \u0436\u0435\u043B\u0435\u0437\u044B (\u0441\u0438\u0441\u0442\u0435\u043C\u043D\u043E) \u0438 \u043F\u0440\u0438 \u043E\u0431\u043B\u044B\u0441\u0435\u043D\u0438\u0438 \u0438 \u043B\u0435\u0447\u0435\u043D\u0438\u0438 \u0443\u0433\u0440\u0435\u0439, \u0441\u0435\u0431\u043E\u0440\u0435\u0438 (\u043C\u0435\u0441\u0442\u043D\u043E)."@ru . . . . "\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u5264(\u3053\u3046\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u3056\u3044\u3001\u82F1\u8A9E:Antiandrogen)\u3068\u306F\u3001\u4EBA\u4F53\u306B\u304A\u3051\u308B\u7537\u6027\u30DB\u30EB\u30E2\u30F3\uFF08\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\uFF09\u306E\u306F\u305F\u3089\u304D\u3092\u6291\u5236\u3059\u308B\u85AC\u7269\u306E\u7DCF\u79F0\u3067\u3042\u308B\u3002\u6297\u7537\u6027\u30DB\u30EB\u30E2\u30F3\u5264\u3068\u3082\u547C\u3070\u308C\u308B\u3002 \u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u526F\u4F5C\u7528\u306F\u3001\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u30BF\u30A4\u30D7\u3068\u7279\u5B9A\u306E\u4F5C\u7528\u306B\u3088\u3063\u3066\u7570\u306A\u308B\u3002\u3044\u305A\u308C\u306B\u305B\u3088\u3001\u7537\u6027\u306B\u304A\u3051\u308B\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u4E00\u822C\u7684\u306A\u526F\u4F5C\u7528\u306B\u306F\u3001\u4E73\u623F\u306E\u5727\u75DB\u3001\u4E73\u623F\u80A5\u5927\u3001\u5973\u6027\u5316\u3001\u307B\u3066\u308A\u3001\u6027\u6A5F\u80FD\u969C\u5BB3\u3001\u4E0D\u598A\u75C7\u3001\u304A\u3088\u3073\u9AA8\u7C97\u9B06\u75C7\u304C\u542B\u307E\u308C\u308B\u3002\u5973\u6027\u306B\u304A\u3044\u3066\u306F\u3001\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306E\u5FCD\u5BB9\u6027\u306F\u306F\u308B\u304B\u306B\u9AD8\u304F\u3001\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u3092\u76F4\u63A5\u30D6\u30ED\u30C3\u30AF\u3059\u308B\u3053\u3068\u306B\u3088\u3063\u3066\u306E\u307F\u6A5F\u80FD\u3059\u308B\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306F\u3001\u6700\u5C0F\u9650\u306E\u526F\u4F5C\u7528\u3092\u3082\u305F\u3089\u3059\u3002\u3057\u304B\u3057\u306A\u304C\u3089\u3001\u30A8\u30B9\u30C8\u30ED\u30B2\u30F3\u306F\u4F53\u5185\u306E\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u304B\u3089\u4F5C\u3089\u308C\u3066\u3044\u308B\u305F\u3081\u3001\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u7523\u751F\u3092\u6291\u5236\u3059\u308B\u6297\u30A2\u30F3\u30C9\u30ED\u30B2\u30F3\u306F\u3001\u9589\u7D4C\u524D\u306E\u5973\u6027\u306B\u30A8\u30B9\u30C8\u30ED\u30B2\u30F3\u30EC\u30D9\u30EB\u306E\u4F4E\u4E0B\u3068\u3001\u307B\u3066\u308A\u3001\u6708\u7D4C\u4E0D\u9806\u3001\u9AA8\u7C97\u9B06\u75C7\u306A\u3069\u306E\u95A2\u9023\u75C7\u72B6\u3092\u5F15\u304D\u8D77\u3053\u3059\u53EF\u80FD\u6027\u304C\u3042\u308B\u3002"@ja . . "Les anti-androg\u00E8nes sont des mol\u00E9cules diminuant l'activit\u00E9 des hormones androg\u00E8nes. Ils bloquent les r\u00E9cepteurs aux androg\u00E8nes ou diminuant la synth\u00E8se des androg\u00E8nes."@fr . . . . . "Steroidal; Nonsteroidal; Peptide"@en . . "Antiandr\u00F3genos, tamb\u00E9m conhecidos como antagonistas de andr\u00F3genos ou bloqueadores de testosterona, s\u00E3o uma classe de medicamentos que previne os andr\u00F3genos, como a testosterona e a di-hidrotestosterona(DHT), de mediar seus efeitos biol\u00F3gicos no organismo. Eles agem bloqueando o receptor androg\u00EAnico (RA) e/ou inibindo ou suprimindo a produ\u00E7\u00E3o de andr\u00F3genos. Eles podem ser considerados os opostos funcionais de agonistas de RA por exemplo andr\u00F3genos e ester\u00F3ides anabolizantes (EA) como testosterona, DHT e nandrolona e moduladores seletivos de receptor de androg\u00EAnio (SARMs) como o enobosarma. Antiandrog\u00EAnios s\u00E3o um dos tr\u00EAs tipos de antagonistas de horm\u00F4nios sexuais, sendo os outroso antiestrog\u00EAnios e o antiprogest\u00F3genos."@pt . . . . . . . . . . . . . . . . . . . . . . "\u6297\u96C4\u6FC0\u7D20"@zh . "\u6297\u96C4\u6FC0\u7D20\uFF08anti-androgens\uFF09\uFF0C\u6216\u7A31\u70BA\u96C4\u6027\u6FC0\u7D20\u62EE\u6297\u5291\uFF08androgen antagonists\uFF09\u3002\u65BC1960\u5E74\u4EE3\u6642\u88AB\u767C\u73FE\uFF0C\u85C9\u7531\u963B\u65B7\u7279\u5B9A\u7684\u53D7\u9AD4\u800C\u6291\u5236\u96C4\u6027\u6FC0\u7D20\u7684\u4F5C\u7528\u3002\u53EF\u4EE5\u7AF6\u722D\u7D30\u80DE\u8868\u9762\u7684\u63A5\u53D7\u5668\u6216\u662F\u5F71\u97FF\u96C4\u6027\u6FC0\u7D20\u7684\u7522\u751F\u3002\u6297\u96C4\u6FC0\u7D20\u53EF\u7528\u4F86\u6CBB\u7642\u4E00\u7CFB\u5217\u7684\u75BE\u75C5\u3002\u5728\u7537\u6027\uFF0C\u6297\u96C4\u6FC0\u7D20\u7D93\u5E38\u7528\u4F86\u6CBB\u7642\u524D\u5217\u817A\u764C\u3002\u5BF9\u5973\u6027\u4F7F\u7528\u901A\u5E38\u7528\u4F86\u6E1B\u5C11\u9AD4\u5167\u904E\u591A\u7684\u96C4\u6027\u6FC0\u7D20\u3002\u6297\u96C4\u6FC0\u7D20\u5C0D\u74B0\u5883\u7684\u5F71\u97FF\u5DF2\u7D93\u53D7\u5230\u9AD8\u5EA6\u7684\u95DC\u6CE8\u3002\u8A31\u591A\u7684\u5DE5\u696D\u5316\u5B78\u7269\u8CEA\u3001\u6BBA\u87F2\u5291\u90FD\u6709\u6297\u96C4\u6FC0\u7D20\u7684\u4F5C\u7528\u3002\u4E00\u4E9B\u7279\u5B9A\u7684\u690D\u7269\u4E5F\u88AB\u767C\u73FE\u6703\u7522\u751F\u6297\u96C4\u6FC0\u7D20\u3002\u74B0\u5883\u4E2D\u7684\u6297\u96C4\u6FC0\u7D20\u5C0D\u65BC\u751F\u6B96\u7CFB\u7D71\u9084\u5728\u767C\u80B2\u7684\u5C0F\u5B69\u6703\u6709\u6DF1\u9060\u7684\u5F71\u97FF\u3002"@zh . . . . . . . . . . "Antiandrogeny jsou l\u00E9ky, kter\u00E9 kompetitivn\u011B blokuj\u00ED \u00FA\u010Dinky androgen\u016F na c\u00EDlov\u00E9 org\u00E1ny \u2013 tj. testikul\u00E1rn\u00ED tk\u00E1\u0148 a tk\u00E1\u0148 nadledvin. V\u00FDsledkem je zablokov\u00E1n\u00ED \u00FA\u010Dink\u016F na prostatickou tk\u00E1\u0148, vlasy, mazov\u00E9 \u017El\u00E1zy a CNS. Indikace: \n* L\u00E9\u010Dba u karcinomu prostaty \n* L\u00E9\u010Dba hirzutismu \n* L\u00E9\u010Dba sexu\u00E1ln\u00EDch deviant\u016F \n* Hormon\u00E1ln\u00ED terapie a l\u00E9\u010Dba genderov\u00E9 dysforie u MtF transgender osob V sexuologii se pou\u017E\u00EDv\u00E1 zejm\u00E9na l\u00E9\u010Dba sexu\u00E1ln\u00EDch deviant\u016F. U spolehliv\u00FDch pacient\u016F se l\u00E1tka u\u017E\u00EDv\u00E1 v podob\u011B tablet, u nespolehliv\u00FDch \u010Di odm\u00EDtaj\u00EDc\u00EDch l\u00E9\u010Dbu v podob\u011B depotn\u00EDch prepar\u00E1t\u016F jednou t\u00FDdn\u011B nebo jednou za 14 dn\u00ED."@cs . . . . . . "Un antiandrogen o antagonista androgen \u00E9s aquell f\u00E0rmac que realitza una supressi\u00F3 hormonal capa\u00E7 de prevenir o inhibir els efectes biol\u00F2gics dels andr\u00F2gens o hormones sexuals masculines en les respostes normals dels teixits corporals a aquestes hormones. Els antiandr\u00F2gens actuen normalment blocant els receptors d'andr\u00F2gens, competint d'aquesta manera amb els llocs d'uni\u00F3 a la superf\u00EDcie de les c\u00E8l\u00B7lules, obstruint literalment la funci\u00F3 dels andr\u00F2gens."@ca . . . . . . . "Antiandrogen"@ca . . . . . . . . . . . . . . . . . . . . . . . "Antiandrogeno"@it . . . . . . . . . . . . . . . "Antyandrogeny"@pl . . . . . . . . . . . . . . .