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Statements

Subject Item
dbr:Sink_condition
rdfs:label
Sink condition
rdfs:comment
In pharmaceutics, sink condition is a term mostly related to the dissolution testing procedure. It means using a sheer volume of solvent, usually about 5 to 10 times greater than the volume present in the saturated solution of the targeted chemical (often the API, and sometimes the excipients) contained in the dosage form being tested.
dcterms:subject
dbc:Drug_delivery_devices dbc:Dosage_forms dbc:Chemical_engineering dbc:Pharmaceutical_industry
dbo:wikiPageID
50210529
dbo:wikiPageRevisionID
953124664
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dbr:Dosage_form dbr:Pharmaceutical_formulation dbr:Active_pharmaceutical_ingredient dbr:Excipients dbr:Solvent dbr:Pharmaceutics dbr:Saturated_solution dbc:Pharmaceutical_industry dbr:Tablet_(pharmacy) dbr:Tablet_hardness_testing dbr:Test_method dbc:Chemical_engineering dbr:Rate_of_solution dbc:Drug_delivery_devices dbr:Dissolution_testing dbc:Dosage_forms dbr:Solubility dbr:Absorption_(pharmacokinetics)
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dbo:abstract
In pharmaceutics, sink condition is a term mostly related to the dissolution testing procedure. It means using a sheer volume of solvent, usually about 5 to 10 times greater than the volume present in the saturated solution of the targeted chemical (often the API, and sometimes the excipients) contained in the dosage form being tested. During the dissolution testing, "sink condition" is a mandatory requirement, otherwise when the concentration begins to get too close to the saturation point, even though the total soluble amount still remains constant, the dissolution rate will gradually begin to reduce in significant amounts, enough to corrupt the test results. .
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wikipedia-en:Sink_condition?oldid=953124664&ns=0
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2452
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wikipedia-en:Sink_condition