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Statements

Subject Item
dbr:Fructosamine_kinase_family
rdf:type
dbo:Protein wikidata:Q206229 wikidata:Q8054 dbo:Biomolecule owl:Thing
rdfs:label
Fructosamine kinase family
rdfs:comment
In molecular biology the fructosamine kinase family is a family of enzymes. This family includes eukaryotic fructosamine-3-kinase enzymes which may initiate a process leading to the deglycation of fructoselysine and of glycated proteins and in the phosphorylation of 1-deoxy-1-morpholinofructose, fructoselysine, fructoseglycine, fructose and glycated lysozyme. The family also includes ketosamine-3-kinases (KT3K). Ketosamines derive from a non-enzymatic reaction between a sugar and a protein. Ketosamine-3-kinases (KT3K) catalyse the phosphorylation of the ketosamine moiety of glycated proteins. The instability of a phosphorylated ketosamine leads to its degradation, and KT3K is thus thought to be involved in protein repair.
dbp:name
Fructosamin_kin
dcterms:subject
dbc:Protein_families
dbo:wikiPageID
32786432
dbo:wikiPageRevisionID
995770211
dbo:wikiPageWikiLink
dbc:Protein_families dbr:Blue-green_algae dbr:Eukaryotes dbr:Eukaryotic dbr:Kinase dbr:Fructosamine-3-kinase dbr:Fructose-6-phosphate dbr:Protein_family dbr:Phosphorylation dbr:Fructose dbr:Escherichia_coli dbr:Proteins dbr:Ketosamine dbr:Homo_sapiens dbr:Lysozyme dbr:Genome dbr:Protein dbr:Enzymes dbr:Prokaryotic dbr:Sugar dbr:Catalyse dbr:Mus_musculus dbr:Glycation
owl:sameAs
n5:4jeSb wikidata:Q5506338 freebase:m.0h3svfq
dbp:wikiPageUsesTemplate
dbt:InterPro_content dbt:Infobox_protein_family dbt:Reflist
dbp:caption
crystal structure of putative fructosamine-3-kinase from thermobifida fusca yx-er1 at 1.85 a resolution
dbp:interpro
IPR016477
dbp:pfam
PF03881
dbp:pfamClan
CL0016
dbp:symbol
Fructosamin_kin
dbo:abstract
In molecular biology the fructosamine kinase family is a family of enzymes. This family includes eukaryotic fructosamine-3-kinase enzymes which may initiate a process leading to the deglycation of fructoselysine and of glycated proteins and in the phosphorylation of 1-deoxy-1-morpholinofructose, fructoselysine, fructoseglycine, fructose and glycated lysozyme. The family also includes ketosamine-3-kinases (KT3K). Ketosamines derive from a non-enzymatic reaction between a sugar and a protein. Ketosamine-3-kinases (KT3K) catalyse the phosphorylation of the ketosamine moiety of glycated proteins. The instability of a phosphorylated ketosamine leads to its degradation, and KT3K is thus thought to be involved in protein repair. The function of the prokaryotic members of this group has not been established. However, several lines of evidence indicate that they may function as fructosamine-3-kinases (FN3K). First, they are similar to characterised FN3K from mouse and human. Second, the Escherichia coli members are found in close proximity on the genome to fructose-6-phosphate kinase (PfkB). Last, FN3K activity has been found in the blue-green algae Anacystis montana indicating such activity-directly demonstrated in eukaryotes-is nonetheless not confined to eukaryotes.
gold:hypernym
dbr:Family
prov:wasDerivedFrom
wikipedia-en:Fructosamine_kinase_family?oldid=995770211&ns=0
dbo:wikiPageLength
3377
dbo:symbol
Fructosamin_kin
foaf:isPrimaryTopicOf
wikipedia-en:Fructosamine_kinase_family