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Statements

Subject Item
dbr:Amino_acid_response
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Amino acid response
rdfs:comment
Amino acid response is the mechanism triggered in mammalian cells by amino acid starvation. The amino acid response pathway is triggered by shortage of any essential amino acid, and results in an increase in activating transcription factor ATF4, which in turn affects many processes by sundry pathways to limit or increase the production of other proteins.
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dbr:ATF4 dbr:Activating_transcription_factor dbr:Leucine_zipper dbr:Membrane_transporter dbr:Metabolic_enzyme dbr:ElF2ɑ dbr:Gcn2 dbr:Growth_factor dbr:Transcription_factor dbr:PCAF dbc:Transcription_factors dbr:Amino_acid
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Amino acid response is the mechanism triggered in mammalian cells by amino acid starvation. The amino acid response pathway is triggered by shortage of any essential amino acid, and results in an increase in activating transcription factor ATF4, which in turn affects many processes by sundry pathways to limit or increase the production of other proteins. Essential amino acids are crucial to maintain homeostasis within an organism. Diet plays an important role in the health of an organism, as evidence ranging from human epidemiological to model organism experimental data suggests that diet-dependent pathways impact a variety of adult stem cells.
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