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Subject Item
dbr:Promegestone
rdf:type
yago:OrganicCompound114727670 yago:Steroid115057744 yago:Part113809207 dbo:ChemicalSubstance yago:WikicatSteroids wikidata:Q8386 yago:Compound114818238 yago:Substance100019613 owl:Thing yago:PhysicalEntity100001930 yago:Chemical114806838 yago:Abstraction100002137 yago:Matter100020827 yago:Material114580897 yago:Relation100031921 n21:ChemicalObject dbo:Drug
rdfs:label
Promegestone
rdfs:comment
Promegestone (INN) (brand name Surgestone), also known as 17α,21-dimethyl-Δ9-19-norprogesterone or 17α,21-dimethyl-19-norpregna-4,9-diene-3,20-dione, is a steroidal progestin of the 19-norprogesterone group which was introduced in 1983 and is marketed in France, Portugal, and Argentina. Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome. Promegestone has weak glucocorticoid activity, but does not bind to the androgen receptor or possess antimineralocorticoid activity. In addition, promegestone has been found to act as a non-competitive antagonist of the nicotinic acetylcholine receptor, similarly to progesterone. The drug is mainly bound to albumin; it does not bind to sex hormone-binding
owl:sameAs
dbpedia-wikidata:Q7249694 n16:06w32q7 yago-res:Promegestone wikidata:Q7249694
dct:subject
dbc:Nicotinic_antagonists dbc:Steroids dbc:Progestogens dbc:Diketones dbc:Glucocorticoids
dbo:wikiPageID
23484695
dbo:wikiPageRevisionID
742701468
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dbo:abstract
Promegestone (INN) (brand name Surgestone), also known as 17α,21-dimethyl-Δ9-19-norprogesterone or 17α,21-dimethyl-19-norpregna-4,9-diene-3,20-dione, is a steroidal progestin of the 19-norprogesterone group which was introduced in 1983 and is marketed in France, Portugal, and Argentina. Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome. Promegestone has weak glucocorticoid activity, but does not bind to the androgen receptor or possess antimineralocorticoid activity. In addition, promegestone has been found to act as a non-competitive antagonist of the nicotinic acetylcholine receptor, similarly to progesterone. The drug is mainly bound to albumin; it does not bind to sex hormone-binding globulin, and binds only weakly to transcortin.
dbo:atcPrefix
G03
dbo:atcSuffix
DB07
dbo:casNumber
34184-77-5
dbo:iupacName
(8S,13S,14S,17S)-13,17-Dimethyl-17-propionyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
dbo:pubchem
36709
dbp:c
22
dbp:chemspiderid
33716
dbp:h
30
dbp:kegg
D08431
dbp:molecularWeight
326.472
dbp:o
2
dbp:smiles
CCC[C@]1C
dbp:stdinchi
1
dbp:stdinchikey
QFFCYTLOTYIJMR-XMGTWHOFSA-N
dbp:synonyms
R-5020; RU-5020
n18:hypernym
dbr:Derivative
Subject Item
dbr:ATC_code_G03DB07
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dbr:Promegestone
Subject Item
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Subject Item
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Subject Item
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foaf:primaryTopic
dbr:Promegestone
Subject Item
dbr:Surgestone
dbo:wikiPageRedirects
dbr:Promegestone