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dbr:Hydroxybupropion
rdf:type
owl:Thing dbo:ChemicalCompound dbo:ChemicalSubstance n17:ChemicalObject wikidata:Q8386 dbo:Drug
rdfs:label
Hydroxybupropion
rdfs:comment
Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion. It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism. With oral bupropion treatment, hydroxybupropion is present in plasma at area under the curve concentrations that are as many as 16–20 times greater than those of bupropion itself, demonstrating extensive conversion of bupropion into hydroxybupropion in humans. As such, hydroxybupropion is likely to play a very important role in the effects of oral bupropion, which could accurately be thought of as functioning largely as a prodrug to hydroxybupropion.
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dbc:Primary_alcohols dbc:Chloroarenes dbc:Human_drug_metabolites dbc:Convulsants dbc:Stimulants dbc:Smoking_cessation dbc:Antidepressants dbc:Cathinones dbc:Nicotinic_antagonists dbc:Norepinephrine_reuptake_inhibitors
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43339210
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722273211
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dbo:abstract
Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion. It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism. With oral bupropion treatment, hydroxybupropion is present in plasma at area under the curve concentrations that are as many as 16–20 times greater than those of bupropion itself, demonstrating extensive conversion of bupropion into hydroxybupropion in humans. As such, hydroxybupropion is likely to play a very important role in the effects of oral bupropion, which could accurately be thought of as functioning largely as a prodrug to hydroxybupropion. Compared to bupropion, hydroxybupropion is similar in its potency as a norepinephrine reuptake inhibitor (IC50 = 1.7 µM) (and likely also acts as a norepinephrine releasing agent, similarly to bupropion), but is substantially weaker as a dopamine reuptake inhibitor (IC50 = >10 µM). Like bupropion, hydroxybupropion is also a non-competitive antagonist of nACh receptors, such as α4β2 and α3β4, but is even more potent in comparison.
dbo:atcPrefix
None
dbo:casNumber
357399-43-0
dbo:iupacName
(±)-1-(3-Chlorophenyl)-2-[(1-hydroxy-2-methyl-2-propanyl)amino]-1-propanone
dbo:pubchem
446
dbp:c
13
dbp:chemspiderid
433
dbp:cl
1
dbp:dependencyLiability
Low
dbp:h
18
dbp:legalStatus
N/A
dbp:molecularWeight
255.741
dbp:n
1
dbp:o
2
dbp:routesOfAdministration
N/A – drug metabolite
dbp:smiles
O=CCC
dbp:stdinchi
1
dbp:stdinchikey
AKOAEVOSDHIVFX-UHFFFAOYSA-N
n15:hypernym
dbr:Metabolite
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dbr:6-Hydroxybupropion
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dbr:Hydroxybupropion
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