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Statements

Subject Item
dbr:Amyloid
dbo:wikiPageWikiLink
dbr:Ure2p
Subject Item
dbr:Fungal_prion
dbo:wikiPageWikiLink
dbr:Ure2p
Subject Item
dbr:Ure2p
rdf:type
yago:WikicatPrions yago:Prion109398935 yago:NaturalObject100019128 yago:Body109224911 yago:PhysicalEntity100001930 yago:Particle109386422 dbo:Protein yago:Object100002684 yago:Whole100003553
rdfs:label
Ure2p
rdfs:comment
Ure2p is a yeast protein that represses transcription of genes involved in nitrogen catabolism. It specifically regulates the utilization of poor nitrogen sources in the presence of preferred nutrients such as ammonia or glutamine. Ure2p is one of the few yeast proteins that are known to be prions. At low frequency the protein adopts an alternative conformation that is auto-catalytic and self-propagating. Yeast cells that carry the protein in the prion conformation are designated as [URE3]. Autocatalytic conversion of Ure2p into the inactive prion form of the protein results in a loss of repression of nitrogen catabolic genes.
dbp:name
Transcriptional regulator URE2
dcterms:subject
dbc:Prions
dbo:wikiPageID
2511645
dbo:wikiPageRevisionID
1111953834
dbo:wikiPageWikiLink
dbr:Protein dbr:Ammonia dbr:Nitrogen dbr:Glutamine dbc:Prions dbr:Nutrient dbr:Yeast dbr:Prion dbr:Autocatalysis
owl:sameAs
yago-res:Ure2p wikidata:Q27550182 freebase:m.07j_th n18:2ZueS
dbp:wikiPageUsesTemplate
dbt:Protein-stub dbt:Technical dbt:Unreferenced_stub dbt:Infobox_nonhuman_protein dbt:Reflist
dbp:auto
yes
dbp:date
December 2009
dbp:organism
Saccharomyces cerevisiae strain S288c
dbp:symbol
URE2
dbp:taxid
559292
dbp:uniprot
P23202
dbo:abstract
Ure2p is a yeast protein that represses transcription of genes involved in nitrogen catabolism. It specifically regulates the utilization of poor nitrogen sources in the presence of preferred nutrients such as ammonia or glutamine. Ure2p is one of the few yeast proteins that are known to be prions. At low frequency the protein adopts an alternative conformation that is auto-catalytic and self-propagating. Yeast cells that carry the protein in the prion conformation are designated as [URE3]. Autocatalytic conversion of Ure2p into the inactive prion form of the protein results in a loss of repression of nitrogen catabolic genes.
dbp:chromosome
XIV
dbp:entrezchromosome
NC_001146.8
dbp:entrezgene
855492
dbp:genlocEnd
220360
dbp:genlocStart
218976
dbp:homologene
22221
dbp:refseqmrna
NM_001183067.1
dbp:refseqprotein
NP_014170.1
gold:hypernym
dbr:Protein
prov:wasDerivedFrom
wikipedia-en:Ure2p?oldid=1111953834&ns=0
dbo:wikiPageLength
1298
foaf:isPrimaryTopicOf
wikipedia-en:Ure2p
Subject Item
dbr:Reed_Wickner
dbo:wikiPageWikiLink
dbr:Ure2p
Subject Item
wikipedia-en:Ure2p
foaf:primaryTopic
dbr:Ure2p