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Statements

Subject Item
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dbo:wikiPageWikiLink
dbr:Sterol_regulatory_element-binding_protein
Subject Item
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Subject Item
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dbr:Sterol_regulatory_element-binding_protein
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dbr:Sterol_regulatory_element-binding_protein
rdf:type
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rdfs:label
SREBP SREBP SREBP SREBP Protein SREB Sterol regulatory element-binding protein
rdfs:comment
Sterol regulatory element-binding proteins (SREBPs) - білок, що регулює обмін стеролів в організмі людини. Головним стеролом в організмі людини є холестерол. У ссавців, цей білок кодується генами SREBF1 та SREBF2 відповідно. Тобто за високого рівня холестеролу він знаходиться в мембрані, за низького – від’єднується від мембрани, проникає в ядро. Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to the nuclear envelope and endoplasmic reticulum membranes. In cells with low levels of sterols, SREBPs are cleaved to a water-soluble N-terminal domain that is translocated to the nucleus. These activated SREBPs then bind to specific sterol regulatory element DNA sequences, thus upregulating the synthesis of enzymes involved in sterol biosynthesis. Sterols in turn inhibit the cleavage of SREBPs and therefore synthesis of additional sterols is reduced through a nega Protein SREB (bahasa Inggris: Sterol regulatory element binding protein, SREBP) merupakan protein yang memiliki berkas genetik yang terletak pada kromosom 17p11.2 dengan ekspresi defisiensi berupa , dan berkas pada kromosom 22q13. Dengan adanya kolesterol di dalam sel, SREBP akan terikat oleh , dan bermigrasi dari retikulum endoplasma menuju Golgi untuk diaktivasi dengan enzim protease agar dapat menjalankan fungsinya sebagai regulator biosintesis sterol. SREBP steht für sterol regulatory element-binding protein. Sterol regulatory element-binding protein-1 (SREBP1) und SREBP2 sind strukturell ähnliche Proteine, die eine entscheidende Rolle bei der Regulation des Cholesterinstoffwechsels haben. Les protéines de liaison à l'élément de régulation des stérols, SREBPs (en anglais : Sterol regulatory element-binding proteins) sont des facteurs de transcription. SREBP står för "Sterol regulatory element-binding protein" och är en transkriptionsfaktor som binder till DNA sekvensen "TCACNCCAC", även kallad "sterol regulatory element". SREBP-1 och SREBP-2 är två isoformer av transkriptionsfaktorn, de är indirekt viktiga för kolesterolsyntesen (SREBP-2), samt upptag och metabolism av fettsyror (SREBP-1). Insulin och kolestrolderivat ökar aktiviteten hos SREBP-1. Den här artikeln är helt eller delvis baserad på material från engelskspråkiga Wikipedia, Sterol regulatory element-binding protein, 20 oktober 2011.
foaf:name
sterol regulatory element-binding transcription factor 2 Sterol regulatory element-binding transcription factor 1
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Sterol regulatory element-binding transcription factor 1 sterol regulatory element-binding transcription factor 2
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dbo:thumbnail
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dbp:omim
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dbp:caption
X-ray crystallography of Sterol Regulatory Element Binding Protein 1A with polydeoxyribonucleotide.
dbp:date
2017-07-04
dbp:symbol
SREBF1 SREBF2
dbp:uniprot
Q12772 P36956
dbp:url
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dbo:abstract
SREBP står för "Sterol regulatory element-binding protein" och är en transkriptionsfaktor som binder till DNA sekvensen "TCACNCCAC", även kallad "sterol regulatory element". SREBP-1 och SREBP-2 är två isoformer av transkriptionsfaktorn, de är indirekt viktiga för kolesterolsyntesen (SREBP-2), samt upptag och metabolism av fettsyror (SREBP-1). Celler behöver kolesterol i ett flertal olika processer, bland annat bildningen av ämnen som gallsalter och kortisol. När kolestrolnivåerna sjunker signalerar cellen detta genom SREBP-2, som inducerar nysyntes av kolesterolmolekyler genom att de enzymer som medierar denna nysyntes transkriberas i större mängder av cellen. Insulin och kolestrolderivat ökar aktiviteten hos SREBP-1. Den här artikeln är helt eller delvis baserad på material från engelskspråkiga Wikipedia, Sterol regulatory element-binding protein, 20 oktober 2011. Les protéines de liaison à l'élément de régulation des stérols, SREBPs (en anglais : Sterol regulatory element-binding proteins) sont des facteurs de transcription. Protein SREB (bahasa Inggris: Sterol regulatory element binding protein, SREBP) merupakan protein yang memiliki berkas genetik yang terletak pada kromosom 17p11.2 dengan ekspresi defisiensi berupa , dan berkas pada kromosom 22q13. Dengan adanya kolesterol di dalam sel, SREBP akan terikat oleh , dan bermigrasi dari retikulum endoplasma menuju Golgi untuk diaktivasi dengan enzim protease agar dapat menjalankan fungsinya sebagai regulator biosintesis sterol. Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to the nuclear envelope and endoplasmic reticulum membranes. In cells with low levels of sterols, SREBPs are cleaved to a water-soluble N-terminal domain that is translocated to the nucleus. These activated SREBPs then bind to specific sterol regulatory element DNA sequences, thus upregulating the synthesis of enzymes involved in sterol biosynthesis. Sterols in turn inhibit the cleavage of SREBPs and therefore synthesis of additional sterols is reduced through a negative feed back loop. SREBP steht für sterol regulatory element-binding protein. Sterol regulatory element-binding protein-1 (SREBP1) und SREBP2 sind strukturell ähnliche Proteine, die eine entscheidende Rolle bei der Regulation des Cholesterinstoffwechsels haben. Sterol regulatory element-binding proteins (SREBPs) - білок, що регулює обмін стеролів в організмі людини. Головним стеролом в організмі людини є холестерол. У ссавців, цей білок кодується генами SREBF1 та SREBF2 відповідно. Тобто за високого рівня холестеролу він знаходиться в мембрані, за низького – від’єднується від мембрани, проникає в ядро.
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1
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SREBF2 SREBF1
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