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Statements

Subject Item
dbr:Neurofibromin_1
dbo:wikiPageWikiLink
dbr:Splicing_regulatory_element
Subject Item
dbr:MBNL1
dbo:wikiPageWikiLink
dbr:Splicing_regulatory_element
Subject Item
dbr:SRE
dbo:wikiPageWikiLink
dbr:Splicing_regulatory_element
dbo:wikiPageDisambiguates
dbr:Splicing_regulatory_element
Subject Item
dbr:Splicing_regulatory_element
rdf:type
dbo:Protein
rdfs:label
Splicing regulatory element
rdfs:comment
Splicing regulatory element (SRE) are cis-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general regulates the constitutive or alternative splicing of this pre-mRNA. SREs recruit trans-acting splicing factors to activate or suppress the splice site recognition or spliceosome assembly. The "context dependence" of SREs is categorized into at least two studied groups: (a) the location-dependent activity of SREs: the activity varies with the relative positions of SREs in pre-mRNA; (b) the gene-dependent activity of SREs: the SRE activity observed in one gene is lost when the SRE is moved to another gene.
dct:subject
dbc:Spliceosome dbc:RNA_splicing
dbo:wikiPageID
40256788
dbo:wikiPageRevisionID
817697040
dbo:wikiPageWikiLink
dbc:Spliceosome dbc:RNA_splicing dbr:Splicing_factor dbr:Precursor_mRNA dbr:Intronic_splicing_enhancer dbr:Intronic_splicing_silencer dbr:Exonic_splicing_enhancer dbr:Exonic_splicing_silencer dbr:Intron dbr:Spliceosome dbr:Exon
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dbo:abstract
Splicing regulatory element (SRE) are cis-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general regulates the constitutive or alternative splicing of this pre-mRNA. SREs recruit trans-acting splicing factors to activate or suppress the splice site recognition or spliceosome assembly. The "context dependence" of SREs is categorized into at least two studied groups: (a) the location-dependent activity of SREs: the activity varies with the relative positions of SREs in pre-mRNA; (b) the gene-dependent activity of SREs: the SRE activity observed in one gene is lost when the SRE is moved to another gene. SREs are: present in exons: exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs)present in introns: (ISEs), (ISSs).
gold:hypernym
dbr:Sequences
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wikipedia-en:Splicing_regulatory_element?oldid=817697040&ns=0
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1351
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wikipedia-en:Splicing_regulatory_element
Subject Item
wikipedia-en:Splicing_regulatory_element
foaf:primaryTopic
dbr:Splicing_regulatory_element