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Statements

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Subject Item: dbr:Signal_recognition_particle
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rdfs:label: Partícula de reconhecimento de sinal (PRS) シグナル認識粒子 جسيم متعرف على الإشارة Particella di riconoscimento del segnale Signal recognition particle Particule de reconnaissance du signal Signalerkennungspartikel 信号识别颗粒 Signal recognition particle Signál rozpoznávající částice Partícula de reconocimiento de señal
rdfs:comment: A PRS é uma das moléculas da rota de secreção de proteínas sintetizadas pelas células. Essa partícula é formada por seis polipeptídeos diferentes mais uma molécula de RNA resultando em um complexo de 325 kDa. Esse complexo ao se ligar ao peptídeo sinal e ao ribossomo causa uma alteração conformacional, ocasionando uma interrupção do polipeptídeo em síntese. Essa interrupção impede a liberação para o citosol de proteínas destinadas ao Retículo Endoplasmático (RE), também é capaz de prevenir dobramentos prematuros da proteína. O complexo PRS-ribossomo se associa ao receptor de PRS presente na superfície do Retículo Endoplasmático Rugoso (RER) com o translocon, que é um poro na membrana do RE por onde o peptídeo recém originado passa. A ligação de PRS e seu receptor resulta em mudanças confor La partícula de reconocimiento de señal (en su sigla inglesa SRP, Signal Recognition Particle) es una ribonucleoproteína implicada en la destinación intracelular de proteínas, que fue descubierta y aislada por Peter Walter y sus colaboradores en 1980. Das Signalerkennungspartikel (englisch signal recognition particle, SRP) ist ein Ribonukleoprotein, das am cotranslationalen Transport von Proteinen in das Endoplasmatische Retikulum (ER) von Eukaryoten und die Plasmamembran von Prokaryoten beteiligt ist. Der Kern des SRP ist universell und in allen sechs biologischen Reichen konserviert. Signal recognition particle eller SRP är ett protein-RNA-komplex bestående av, i fallet för Gramnegativa bakterier, Ffh protein och 4.5S RNA som känner igen den hydrofoba signalsekvens som de proteiner som ska passera ett membran (ER för eukaryoter och cellmembranet för bakterier och arkéer) har nära N-terminalen. Detta innefattar bland annat proteiner som ska exocyteras, membranproteiner och lysosomproteiner. Signál rozpoznávající částice (SRP, český překlad anglického výrazu signal recognition particle není ustálen) je velký komplex (tzv. ribonukleoprotein) složený z RNA a bílkovin. Obvykle má velikost 325 kilodaltonů a zahrnuje konkrétně o délce 300 nukleotidů a šest různých polypeptidů. جسيم متعرف على الإشارة (بالإنجليزية: Signal recognition particle)‏ هو بروتين رنوي (مركب بروتين-رنا) وفير متواجد في العصارة الخلوية ومحفوظ عالميا، يقوم بالتعرف على بروتينات محددة وتوجيهها إلى الشبكة الإندوبلازمية لدى حقيقيات النوى وإلى الغشاء البلازمي لدى بدائيات النوى. シグナル認識粒子（シグナルにんしきりゅうし、英: signal recognition particle、略称: SRP）は、細胞質に豊富に存在する、普遍的に保存されたリボヌクレオタンパク質（タンパク質-RNA複合体）である。SRPは、真核生物では小胞体へ、原核生物では細胞膜へ向かう特定のタンパク質を認識し、その輸送に関与する。信号识别颗粒（英語：Signal recognition particle，简称为SRP）是一种存在于胞质溶胶中大量、普遍存在且进化保守的核糖核蛋白（蛋白质-RNA复合体），它可以识别特定的蛋白质，并将它们对准投放到真核细胞的内质网/原核生物的质膜上。 The signal recognition particle (SRP) is an abundant, cytosolic, universally conserved ribonucleoprotein (protein-RNA complex) that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes. La particella di riconoscimento del segnale (SRP, dall'inglese signal recognition particle) è una ribonucleoproteina che riconosce e trasporta le proteine verso la parete citosolica del reticolo endoplasmatico ruvido.L'SRP riconosce e lega la sequenza segnale presente all'estremità N-terminale dei polipeptidi destinati al sistema endomembranoso e permette l'adesione alla membrana del reticolo endoplasmatico. La particule de reconnaissance du signal (PRS) (en anglais : Signal Recognition Particle ou SRP) est un complexe de protéines et d'ARN. Elle sert à fixer des ribosomes sur le réticulum endoplasmique chez les eucaryotes ou sur la membrane plasmique chez les procaryotes, par reconnaissance d'un peptide signal spécifique.
foaf:name: signal recognition particle 19kDa signal recognition particle 72kDa signal recognition particle 54kDa signal recognition particle 68kDa signal recognition particle 9kDa signal recognition particle 14kDa
dbp:name: signal recognition particle 72kDa Signal recognition particle protein signal recognition particle 54kDa signal recognition particle 68kDa signal recognition particle 9kDa signal recognition particle 14kDa signal recognition particle 19kDa
foaf:depiction: n11:PDB_1lng_EBI.jpg n11:PDB_1mfq_EBI.jpg
dct:subject: dbc:Cell_signaling
dbo:wikiPageID: 349467
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dbp:altsymbols: p48, Srp54
dbp:bot: InternetArchiveBot
dbp:date: October 2022
dbp:fixAttempted: yes
dbp:organism: Escherichia coli
dbp:symbol: SRP14 SRP9 SRP68 SRP72 ffh SRP19 SRP54
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dbo:abstract: 信号识别颗粒（英語：Signal recognition particle，简称为SRP）是一种存在于胞质溶胶中大量、普遍存在且进化保守的核糖核蛋白（蛋白质-RNA复合体），它可以识别特定的蛋白质，并将它们对准投放到真核细胞的内质网/原核生物的质膜上。 La particella di riconoscimento del segnale (SRP, dall'inglese signal recognition particle) è una ribonucleoproteina che riconosce e trasporta le proteine verso la parete citosolica del reticolo endoplasmatico ruvido.L'SRP riconosce e lega la sequenza segnale presente all'estremità N-terminale dei polipeptidi destinati al sistema endomembranoso e permette l'adesione alla membrana del reticolo endoplasmatico. The signal recognition particle (SRP) is an abundant, cytosolic, universally conserved ribonucleoprotein (protein-RNA complex) that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes. La partícula de reconocimiento de señal (en su sigla inglesa SRP, Signal Recognition Particle) es una ribonucleoproteína implicada en la destinación intracelular de proteínas, que fue descubierta y aislada por Peter Walter y sus colaboradores en 1980. Signal recognition particle eller SRP är ett protein-RNA-komplex bestående av, i fallet för Gramnegativa bakterier, Ffh protein och 4.5S RNA som känner igen den hydrofoba signalsekvens som de proteiner som ska passera ett membran (ER för eukaryoter och cellmembranet för bakterier och arkéer) har nära N-terminalen. Detta innefattar bland annat proteiner som ska exocyteras, membranproteiner och lysosomproteiner. SRP binder till signalsekvensen som sticker ut från ribosomen under translatering. När ribosom-SRP komplexet diffunderat till membranet binder det till FtsY som i sin tur binder till en translokon, med vilken proteinet kan transporteras genom membranet. Das Signalerkennungspartikel (englisch signal recognition particle, SRP) ist ein Ribonukleoprotein, das am cotranslationalen Transport von Proteinen in das Endoplasmatische Retikulum (ER) von Eukaryoten und die Plasmamembran von Prokaryoten beteiligt ist. Der Kern des SRP ist universell und in allen sechs biologischen Reichen konserviert. La particule de reconnaissance du signal (PRS) (en anglais : Signal Recognition Particle ou SRP) est un complexe de protéines et d'ARN. Elle sert à fixer des ribosomes sur le réticulum endoplasmique chez les eucaryotes ou sur la membrane plasmique chez les procaryotes, par reconnaissance d'un peptide signal spécifique. Signál rozpoznávající částice (SRP, český překlad anglického výrazu signal recognition particle není ustálen) je velký komplex (tzv. ribonukleoprotein) složený z RNA a bílkovin. Obvykle má velikost 325 kilodaltonů a zahrnuje konkrétně o délce 300 nukleotidů a šest různých polypeptidů. SRP má důležitou funkci v regulaci procesu translace („výroby bílkovin na ribozomech“). Když ribozom začne vyrábět bílkovinu určenou pro syntézu na endoplazmatickém retikulu (ER), naváže se SRP na ribozom a N-terminální na bílkovině. Touto vazbou se dočasně přeruší syntéza bílkoviny a celý translační komplex (SRP, ribozom, mRNA a začínající bílkovina) se přesune na membránu endoplazmatického retikula. Na membráně se naváže na a opět se obnoví translace. Důsledkem je skutečnost, že rostoucí bílkovinný řetězec začne procházet skrz membránu ER a nakonec se celý uvolňuje do lumen. Po dokončení translace se SRP a celý translační ribozomální komplex odpojí od SRP receptoru a v cytosolu čeká na další mRNA. جسيم متعرف على الإشارة (بالإنجليزية: Signal recognition particle)‏ هو بروتين رنوي (مركب بروتين-رنا) وفير متواجد في العصارة الخلوية ومحفوظ عالميا، يقوم بالتعرف على بروتينات محددة وتوجيهها إلى الشبكة الإندوبلازمية لدى حقيقيات النوى وإلى الغشاء البلازمي لدى بدائيات النوى. A PRS é uma das moléculas da rota de secreção de proteínas sintetizadas pelas células. Essa partícula é formada por seis polipeptídeos diferentes mais uma molécula de RNA resultando em um complexo de 325 kDa. Esse complexo ao se ligar ao peptídeo sinal e ao ribossomo causa uma alteração conformacional, ocasionando uma interrupção do polipeptídeo em síntese. Essa interrupção impede a liberação para o citosol de proteínas destinadas ao Retículo Endoplasmático (RE), também é capaz de prevenir dobramentos prematuros da proteína. O complexo PRS-ribossomo se associa ao receptor de PRS presente na superfície do Retículo Endoplasmático Rugoso (RER) com o translocon, que é um poro na membrana do RE por onde o peptídeo recém originado passa. A ligação de PRS e seu receptor resulta em mudanças conformacionais, dissociando o complexo PRS e seu receptor, assim como, o do complexo ribossomo-translocon devido à hidrólise mútua de GTPs a GDP. シグナル認識粒子（シグナルにんしきりゅうし、英: signal recognition particle、略称: SRP）は、細胞質に豊富に存在する、普遍的に保存されたリボヌクレオタンパク質（タンパク質-RNA複合体）である。SRPは、真核生物では小胞体へ、原核生物では細胞膜へ向かう特定のタンパク質を認識し、その輸送に関与する。
dbp:arm: q
dbp:band: 42.12 25.1 13.2 11 22 21
dbp:chromosome: 17 14 15 4 5 1
dbp:entrezgene: 6726 6727 6730 6731 6728 6729
dbp:hgncid: 11300 11301 11302 11303 11299 11304
dbp:locussupplementarydata: -q22
dbp:refseq: NM_003136 NM_003133 NM_006947 NM_003135 NM_003134 NM_014230
dbo:locusSupplementaryData: -q22
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dbo:band: 25.1 42.12 13.2 22 21 11
dbo:chromosome: 14 5 15 4 1 17
dbo:entrezgene: 6731 6730 6727 6729 6728 6726
dbo:hgncid: 11299 11302 11300 11303 11304 11301
dbo:refseq: NM_003136 NM_003135 NM_003133 NM_003134 NM_006947 NM_014230
dbo:uniprot: O76094 P09132 P61011 P49458 P37108 Q9UHB9
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dbo:symbol: SRP54 SRP68 SRP9 SRP72 SRP19 SRP14
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