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Statements

Subject Item
dbr:List_of_cis-regulatory_RNA_elements
dbo:wikiPageWikiLink
dbr:P27_cis-regulatory_element
Subject Item
dbr:Induced_cell_cycle_arrest
dbo:wikiPageWikiLink
dbr:P27_cis-regulatory_element
Subject Item
dbr:P27_cis-regulatory_element
rdf:type
yago:PsychologicalFeature100023100 yago:Content105809192 yago:Component105868954 yago:Cognition100023271 yago:Concept105835747 yago:WikicatCis-regulatoryRNAElements yago:Idea105833840 yago:Part105867413 yago:Abstraction100002137
rdfs:label
P27 cis-regulatory element
rdfs:comment
The p27 cis-regulatory element is a structured G/C rich RNA element which is involved in controlling cell cycle regulated translation of the p27kip protein in human cells. The p27kip1 protein is involved in cell cycle regulation and belongs to the Cip/Kip family of cyclin dependent kinase(CDK)inhibitors. These inhibitors possess an N-terminal CDK-inhibitory domain which binds to the ATP binding pocket of the kinase and modulates its function. This element was initially characterised in human cells but has predicted homologs in mice and chickens.
dbp:name
p27 cis-regulatory element
foaf:depiction
n16:RF00454.jpg
dct:subject
dbc:Cis-regulatory_RNA_elements
dbo:wikiPageID
11421341
dbo:wikiPageRevisionID
994583761
dbo:wikiPageWikiLink
dbr:Cis-regulatory_element dbr:Eukaryota dbc:Cis-regulatory_RNA_elements dbr:Sequence_conservation dbr:Secondary_structure dbr:Cyclin_dependent_kinase dbr:P27_(gene) dbr:Amino_acids dbr:MRNA dbr:Adenosine_triphosphate dbr:5' dbr:GC-content dbr:Cell_cycle dbr:Translation_(biology) dbr:Thermodynamic_free_energy dbr:5'UTR dbr:Nucleotides dbr:Stem-loop
owl:sameAs
yago-res:P27_cis-regulatory_element n14:4sd2w freebase:m.02rbznp wikidata:Q7117855
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dbr:Eukaryota
dbp:wikiPageUsesTemplate
dbt:Infobox_rfam dbt:Reflist dbt:Rfam dbt:SO
dbo:thumbnail
n16:RF00454.jpg?width=300
dbp:caption
Predicted secondary structure and sequence conservation of p27_CRE
dbp:id
RF00454
dbp:symbol
p27_CRE
dbo:abstract
The p27 cis-regulatory element is a structured G/C rich RNA element which is involved in controlling cell cycle regulated translation of the p27kip protein in human cells. The p27kip1 protein is involved in cell cycle regulation and belongs to the Cip/Kip family of cyclin dependent kinase(CDK)inhibitors. These inhibitors possess an N-terminal CDK-inhibitory domain which binds to the ATP binding pocket of the kinase and modulates its function. This p27 cis-regulatory element is 114 nucleotides in length and is located at the very 5' end of the 5'UTR of the p27 mRNA. It contains a small open reading frame (ORF) of 29 amino acids which is preceded by and overlaps with a G/C-rich hairpin domain. This hairpin domain is predicted to form multiple stable stem loops with similar free energy. Both the open reading frame and the stem loop elements contribute to cell cycle-regulated translation of the p27 mRNA. The structure of the G/C rich element appears to be important to its regulatory function as replacement of the G/C rich region with an unstructured sequence has a greater effect on regulation of translation than a simple deletion of part of the G/C rich region. It has been suggested that cell cycle specific binding proteins may favour one of the predicted structures in the G/C region thereby promoting conformational states which could regulate downstream translation. This element was initially characterised in human cells but has predicted homologs in mice and chickens.
dbp:rfam
RF00454
dbp:rnaType
dbr:Cis-regulatory_element
gold:hypernym
n20:
prov:wasDerivedFrom
wikipedia-en:P27_cis-regulatory_element?oldid=994583761&ns=0
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3619
foaf:isPrimaryTopicOf
wikipedia-en:P27_cis-regulatory_element
Subject Item
dbr:CDKN1B
dbo:wikiPageWikiLink
dbr:P27_cis-regulatory_element
Subject Item
dbr:Patrizia_Casaccia
dbo:wikiPageWikiLink
dbr:P27_cis-regulatory_element
Subject Item
wikipedia-en:P27_cis-regulatory_element
foaf:primaryTopic
dbr:P27_cis-regulatory_element