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Statements

Subject Item
dbr:Calcium-activated_potassium_channel_subunit_alpha-1
dbo:wikiPageWikiLink
dbr:KCNMB2
Subject Item
dbr:Index_of_biophysics_articles
dbo:wikiPageWikiLink
dbr:KCNMB2
Subject Item
dbr:Limbic-predominant_age-related_TDP-43_encephalopathy
dbo:wikiPageWikiLink
dbr:KCNMB2
Subject Item
dbr:List_of_human_protein-coding_genes_2
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dbr:KCNMB2
Subject Item
dbr:KCNMB2_(gene)
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dbr:KCNMB2
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dbr:KCNMB2
Subject Item
dbr:Calcium-activated_potassium_channel
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dbr:KCNMB2
Subject Item
dbr:KCNMB2
rdf:type
yago:Organization108008335 dbo:HumanGene wikidata:Q206229 owl:Thing yago:Unit108189659 yago:Family108078020 yago:SocialGroup107950920 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Gene dbo:Biomolecule wikidata:Q7187 dbo:Protein yago:Abstraction100002137 yago:Group100031264
rdfs:label
KCNMB2 KCNMB2
rdfs:comment
Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene. Big Potassium (BK) channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. BK channels can contain two distinct subunits: a pore-forming alpha subunit and a modulatory beta subunit. Each complete BK channel contains four copies of the pore-forming alpha subunit and up to four beta subunits. The protein encoded by the KCNMB2 gene is an auxiliary beta subunit which influences the calcium sensitivity of BK currents and, following activation of BK current, causes persistent inactivation. The subunit encoded by the KCNMB2 gene is expressed in various endocrine cells, including KCNMB2 (англ. Potassium calcium-activated channel subfamily M regulatory beta subunit 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 235 амінокислот, а молекулярна маса — 27 130. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин
dbp:name
KCNMB2, ball and chain domain
foaf:depiction
n10:PDB_1jo6_EBI.jpg
dct:subject
dbc:Ion_channels dbc:Protein_domains
dbo:wikiPageID
14879381
dbo:wikiPageRevisionID
1073041995
dbo:wikiPageWikiLink
dbr:KCNMB1 dbr:N-terminus dbr:N-terminal dbc:Ion_channels dbr:Cytoplasmic dbr:Ball_and_chain_inactivation dbr:Potassium_channel dbr:Protein_domains dbr:Protein dbr:KCNMB3 dbr:KCNMB4 dbr:Gene dbr:BK_channel dbc:Protein_domains dbr:Calcium-activated_potassium_channel_beta_subunit dbr:Voltage-gated_potassium_channel
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dbo:thumbnail
n10:PDB_1jo6_EBI.jpg?width=300
dbp:caption
solution structure of the cytoplasmic n-terminus of the bk beta-subunit kcnmb2
dbp:interpro
IPR015382
dbp:pfam
PF09303
dbp:symbol
KcnmB2_inactiv
dbo:abstract
Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene. Big Potassium (BK) channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. BK channels can contain two distinct subunits: a pore-forming alpha subunit and a modulatory beta subunit. Each complete BK channel contains four copies of the pore-forming alpha subunit and up to four beta subunits. The protein encoded by the KCNMB2 gene is an auxiliary beta subunit which influences the calcium sensitivity of BK currents and, following activation of BK current, causes persistent inactivation. The subunit encoded by the KCNMB2 gene is expressed in various endocrine cells, including pancreas and adrenal chromaffin cells. It is also found in the brain, including the hippocampus. The KCNMB2 gene is homologous to three other genes found in mammalian genomes: KCNMB1 (found primarily in smooth muscle), KCNMB3, and KCNMB4 (the primary brain BK auxiliary subunit). Calcium-activated potassium channel subunit beta-2 comprises two domains. An N-terminal cytoplasmic domain, the ball and chain domain, which is responsible for the fast inactivation of these channels, and a C-terminal calcium-activated potassium channel beta subunit domain. The N-terminal domain only occurs in calcium-activated potassium channel subunit beta-2, while the C-terminal domain is found in related proteins. KCNMB2 (англ. Potassium calcium-activated channel subfamily M regulatory beta subunit 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 235 амінокислот, а молекулярна маса — 27 130. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до іонних каналів. Задіяний у таких біологічних процесах як транспорт іонів, транспорт. Локалізований у мембрані.
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Subject Item
dbr:BK_channel
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dbr:KCNMB2
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dbr:KCNMB2
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dbr:KCNMB2
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wikipedia-en:KCNMB2
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dbr:KCNMB2