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Statements

Subject Item
dbr:Interferon_gamma
dbo:wikiPageWikiLink
dbr:Interferon_gamma_5'_UTR_regulatory_element
Subject Item
dbr:Interferon_gamma_5'_UTR_regulatory_element
rdf:type
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rdfs:label
Interferon gamma 5' UTR regulatory element
rdfs:comment
Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma.
dbp:name
300.0
foaf:depiction
n4:RF00259.jpg
dct:subject
dbc:Cis-regulatory_RNA_elements
dbo:wikiPageID
11421130
dbo:wikiPageRevisionID
1032092351
dbo:wikiPageWikiLink
dbr:Secondary_structure dbr:Cis-regulatory_element dbr:Pseudoknot dbr:Interferon-gamma dbc:Cis-regulatory_RNA_elements dbr:RNA dbr:Sequence_conservation dbr:Protein_kinase_R dbr:Eukaryota
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dbo:thumbnail
n4:RF00259.jpg?width=300
dbp:caption
Predicted secondary structure and sequence conservation of IFN_gamma
dbp:id
RF00259
dbp:symbol
IFN_gamma
dbo:abstract
Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma.
dbp:rfam
RF00259
dbp:rnaType
dbr:Cis-regulatory_element
gold:hypernym
dbr:Family
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wikipedia-en:Interferon_gamma_5'_UTR_regulatory_element?oldid=1032092351&ns=0
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