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Statements

Subject Item
dbr:Epidermal_differentiation_complex
rdfs:label
Epidermal differentiation complex
rdfs:comment
The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and cornification of keratinocytes, the primary cell type of the epidermis. In humans, the complex is located on a 1.9 Mbp stretch within chromosome 1q21. The proteins encoded by EDC genes are closely related in terms of function, and evolutionarily they belong to three distinct gene families: the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family.
dcterms:subject
dbc:Genes_on_human_chromosome_1 dbc:Skin dbc:Gene_complexes
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49504353
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1081651344
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dbo:abstract
The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and cornification of keratinocytes, the primary cell type of the epidermis. In humans, the complex is located on a 1.9 Mbp stretch within chromosome 1q21. The proteins encoded by EDC genes are closely related in terms of function, and evolutionarily they belong to three distinct gene families: the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family. It has been hypothesized that the clustering of EDC genes occurred due to duplication events which were evolutionarily favored during the adaptation to terrestrial environments. EDC proteins have been involved in a variety of skin disorders including ichthyosis vulgaris, atopic dermatitis and psoriasis.
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Subject Item
dbr:Jumping_translocation_breakpoint
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dbr:Epidermal_differentiation_complex
Subject Item
dbr:EDC
dbo:wikiPageWikiLink
dbr:Epidermal_differentiation_complex
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dbr:Epidermal_differentiation_complex
Subject Item
dbr:C1orf68
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dbr:Epidermal_differentiation_complex
Subject Item
dbr:Filaggrin
dbo:wikiPageWikiLink
dbr:Epidermal_differentiation_complex
Subject Item
dbr:Extracellular_matrix_protein_1
dbo:wikiPageWikiLink
dbr:Epidermal_differentiation_complex
Subject Item
dbr:SPRR3
dbo:wikiPageWikiLink
dbr:Epidermal_differentiation_complex
Subject Item
dbr:Trichohyalin
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dbr:Epidermal_differentiation_complex
Subject Item
wikipedia-en:Epidermal_differentiation_complex
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dbr:Epidermal_differentiation_complex