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Statements

Subject Item
dbr:List_of_opioids
dbo:wikiPageWikiLink
dbr:Endomorphin
Subject Item
dbr:Melanocyte-inhibiting_factor
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dbr:Endomorphin
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rdfs:label
Endomorphin
rdfs:comment
Endomorphins are considered to be natural opioid neurotransmitters central to pain relief. The two known endomorphins, endomorphin-1 and endomorphin-2, are tetrapeptides, consisting of Tyr-Pro-Trp-Phe and Tyr-Pro-Phe-Phe amino acid sequences respectively. These sequences fold into tertiary structures with high specificity and affinity for the μ-opioid receptor, binding it exclusively and strongly. Bound μ-opioid receptors typically induce inhibitory effects on neuronal activity. Endomorphin-like immunoreactivity exists within the central and peripheral nervous systems, where endomorphin-1 appears to be concentrated in the brain and upper brainstem, and endomorphin-2 in the spinal cord and lower brainstem. Because endomorphins activate the μ-opioid receptor, which is the target receptor of
foaf:name
Endomorphin-1 Endomorphin-2
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Endomorphin-1 Endomorphin-2
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-1
dbp:othernames
Tyr-Pro-Trp-Phe-NH2; (L)-Tyrosyl-(L)-prolyl-(L)-tryptophyl-(L)-phenylalaninamide Tyr-Pro-Phe-Phe-NH2; (L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide
dbo:abstract
Endomorphins are considered to be natural opioid neurotransmitters central to pain relief. The two known endomorphins, endomorphin-1 and endomorphin-2, are tetrapeptides, consisting of Tyr-Pro-Trp-Phe and Tyr-Pro-Phe-Phe amino acid sequences respectively. These sequences fold into tertiary structures with high specificity and affinity for the μ-opioid receptor, binding it exclusively and strongly. Bound μ-opioid receptors typically induce inhibitory effects on neuronal activity. Endomorphin-like immunoreactivity exists within the central and peripheral nervous systems, where endomorphin-1 appears to be concentrated in the brain and upper brainstem, and endomorphin-2 in the spinal cord and lower brainstem. Because endomorphins activate the μ-opioid receptor, which is the target receptor of morphine and its derivatives, endomorphins possess significant potential as analgesics with reduced side effects and risk of addiction.
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Tyr-Pro-Trp-Phe-NH2; (L)-Tyrosyl-(L)-prolyl-(L)-tryptophyl-(L)-phenylalaninamide Tyr-Pro-Phe-Phe-NH2; (L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide
dbo:iupacName
(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-{{!((}}(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-{{!((}}(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
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