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Statements

Subject Item
dbr:List_of_EC_numbers_(EC_3)
dbo:wikiPageWikiLink
dbr:DNA-deoxyinosine_glycosylase
Subject Item
dbr:DNA-deoxyinosine_glycosylase
rdf:type
yago:Chemical114806838 yago:Macromolecule114944888 yago:Activator114723079 wikidata:Q206229 yago:Matter100020827 dbo:Enzyme yago:Protein114728724 wikidata:Q8047 yago:Enzyme114732946 yago:OrganicCompound114727670 yago:Unit109465459 yago:Relation100031921 yago:Catalyst114723628 yago:Molecule114682133 yago:Thing100002452 yago:Substance100019613 dbo:Biomolecule yago:Compound114818238 yago:Material114580897 yago:Abstraction100002137 yago:Part113809207 owl:Thing yago:PhysicalEntity100001930 dbo:Protein
rdfs:label
DNA-デオキシイノシングリコシラーゼ DNA-deoxyinosine glycosylase
rdfs:comment
DNA-deoxyinosine glycosylase (EC 3.2.2.15, DNA(hypoxanthine) glycohydrolase, deoxyribonucleic acid glycosylase, hypoxanthine-DNA glycosylase) is an enzyme with systematic name DNA-deoxyinosine deoxyribohydrolase. This enzyme is involved in DNA damage repair and targets hypoxanthine bases. DNA-デオキシイノシングリコシラーゼ(DNA-deoxyinosine glycosylase、EC 3.2.2.15)は、デオキシリボ核酸(DNA)及びポリヌクレオチドを加水分解し、ヒポキサンチンを遊離させる反応を触媒する酵素である。系統名は、DNA-デオキシイノシン デオキシリボヒドロラーゼ(DNA-deoxyinosine deoxyribohydrolase)である。
foaf:name
DNA-deoxyinosine glycosylase
dbp:name
DNA-deoxyinosine glycosylase
foaf:depiction
n4:PDB_4skn_EBI.jpg
dcterms:subject
dbc:EC_3.2.2
dbo:wikiPageID
39105823
dbo:wikiPageRevisionID
1118726036
dbo:wikiPageWikiLink
dbr:Hydrolase dbr:N-glycosidic_bond dbr:Base_excision_repair n15:pdb dbr:Uracil-DNA_glycosylase dbr:Enzyme_classification dbr:Glycosyl dbr:Glycosylase dbc:EC_3.2.2 dbr:List_of_enzymes n21:PDB_4skn_EBI.jpg dbr:AP_site dbr:Enzyme
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dbpedia-sr:DNK-dezoksiinozinska_glikozilaza freebase:m.0t545sz wikidata:Q11216994 dbpedia-sh:DNK-dezoksiinozinska_glikozilaza n22:BZmi dbpedia-ja:DNA-デオキシイノシングリコシラーゼ
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dbt:Portal_bar dbt:Enzymes dbt:Infobox_enzyme dbt:EC_number dbt:Reflist dbt:MeshName dbt:Sugar_hydrolases
dbo:thumbnail
n4:PDB_4skn_EBI.jpg?width=300
dbp:casNumber
68247
dbp:ecNumber
3.2
dbp:iubmbEcNumber
3
dbo:abstract
DNA-デオキシイノシングリコシラーゼ(DNA-deoxyinosine glycosylase、EC 3.2.2.15)は、デオキシリボ核酸(DNA)及びポリヌクレオチドを加水分解し、ヒポキサンチンを遊離させる反応を触媒する酵素である。系統名は、DNA-デオキシイノシン デオキシリボヒドロラーゼ(DNA-deoxyinosine deoxyribohydrolase)である。 DNA-deoxyinosine glycosylase (EC 3.2.2.15, DNA(hypoxanthine) glycohydrolase, deoxyribonucleic acid glycosylase, hypoxanthine-DNA glycosylase) is an enzyme with systematic name DNA-deoxyinosine deoxyribohydrolase. This enzyme is involved in DNA damage repair and targets hypoxanthine bases. DNA is constantly exposed to chemical reactions within its cellular environment, leading to undesired structural changes and compromising the integrity of genetic information. Common changes to bases include oxidation, alkylation, or the deamination of bases. Observed deamination in DNA bases are cytosine to uracil, guanine to xanthine and oxanine, or adenine to hypoxanthine. These single-base legions are removed through the base excision repair (BER) pathway, a mechanism initiated by DNA glycosylase to remove a mismatch or mutated base. DNA glycosylases are ubiquitous, observed in species of all kingdoms of life, including archaea, eubacteria, eukaryotes, and large DNA viruses. They can be further subdivided into four specific categories: the uracil DNA glycosylases (UDGs), the helix-hairpin-helix (HhH) glycosylases, the 3-methyl-purine glycosylase (MPG), and the endonuclease VIII-like (NEIL) glycosylases. However, DNA deoxyinosine glycosylase activity, the removal of a hypoxanthine base, is observed within the uracil DNA glycosylase superfamily. Currently, there are 6 families within the DNA Uracil Glycosylase superfamily, each classified based on their sequence homology, and biochemical and structural similarities. Uracil and hypoxanthine activity is a feature that is particular to UDG families, namely family 3 SMUG1-like enzymes and more recently the newly identified family 6 enzymes, which exhibits only hypoxanthine activity specifically.
gold:hypernym
dbr:Enzyme
prov:wasDerivedFrom
wikipedia-en:DNA-deoxyinosine_glycosylase?oldid=1118726036&ns=0
dbo:wikiPageLength
10621
dbo:ecNumber
3.2.2.15
foaf:isPrimaryTopicOf
wikipedia-en:DNA-deoxyinosine_glycosylase
Subject Item
dbr:DNA(hypoxanthine)_glycohydrolase
dbo:wikiPageWikiLink
dbr:DNA-deoxyinosine_glycosylase
dbo:wikiPageRedirects
dbr:DNA-deoxyinosine_glycosylase
Subject Item
dbr:DNA-deoxyinosine_deoxyribohydrolase
dbo:wikiPageWikiLink
dbr:DNA-deoxyinosine_glycosylase
dbo:wikiPageRedirects
dbr:DNA-deoxyinosine_glycosylase
Subject Item
dbr:Hypoxanthine-DNA_glycosylase
dbo:wikiPageWikiLink
dbr:DNA-deoxyinosine_glycosylase
dbo:wikiPageRedirects
dbr:DNA-deoxyinosine_glycosylase
Subject Item
dbr:EC_3.2.2.15
dbo:wikiPageWikiLink
dbr:DNA-deoxyinosine_glycosylase
dbo:wikiPageRedirects
dbr:DNA-deoxyinosine_glycosylase
Subject Item
dbr:Deoxyribonucleic_acid_glycosylase
dbo:wikiPageWikiLink
dbr:DNA-deoxyinosine_glycosylase
dbo:wikiPageRedirects
dbr:DNA-deoxyinosine_glycosylase
Subject Item
wikipedia-en:DNA-deoxyinosine_glycosylase
foaf:primaryTopic
dbr:DNA-deoxyinosine_glycosylase