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Subject Item: dbr:Cannabidiol
dbo:wikiPageWikiLink: dbr:Cannabinoid_receptor

Subject Item: dbr:Cannabigerol
dbo:wikiPageWikiLink: dbr:Cannabinoid_receptor

Subject Item: dbr:Cannabinoid_receptor
rdf:type: yago:Macromolecule114944888 yago:Abstraction100002137 yago:Molecule114682133 dbo:Biomolecule wikidata:Q206229 yago:Sequence108459252 yago:Compound114818238 yago:Group100031264 yago:Series108457976 umbel-rc:ProteinMolecule yago:Chemical114806838 yago:WikicatGenesOnChromosome6 yago:WikicatGenesOnChromosome1 yago:Relation100031921 yago:Ordering108456993 yago:Part113809207 yago:Thing100002452 yago:Material114580897 yago:OrganicCompound114727670 yago:Protein114728724 wikidata:Q8054 owl:Thing yago:Matter100020827 dbo:Protein yago:PhysicalEntity100001930 yago:Arrangement107938773 yago:Substance100019613 yago:Unit109465459 yago:Gene105436752
rdfs:label: Cannabinoïdereceptor Receptor canabinoide Cannabinoidreceptorer Kanabinoidní receptor Receptor de cannabinoides مستقبل كانابينويد Receptory kannabinoidowe Канабіноїдні рецептори Receptor cannabinoide Cannabinoid receptor Каннабиноидные рецепторы Recettori cannabinoidi Endocannabinoid-System
rdfs:comment: مستقبل الكانابينويد هو عضو من عائلة مستقبل مقترن بالبروتين ج ، أو المستقبل السباعي عبر الغشاء.و تم اكتشاف نوعين من من مستقبلات الكانابيويد ، مستقبل كانابينويد من النوع الأول (CB1) و مستقبل كانابينويد من النوع الثاني (CB2) و مستقبلات الكانابينويد هذه يتم تفعليها عن طريق ارتباطها بأحد الجزيئات الحيوية التالية : * الكانابينويد الداخلي أو الإندوكانابينويد * الكانابينويد التَخْليقِيّ * الكانابينويد النباتي (ينتج من نبات قنب هندي) Das Endocannabinoid-System (Abk. für endogenes Cannabinoid-System) ist ein Teil des Nervensystems und umfasst die Cannabinoid-Rezeptoren CB1 und CB2 mit ihren natürlichen Liganden und der nachgeschalteten intrazellulären Signaltransduktion nach der Ligandenbindung in Vertebraten. Cannabinoïdereceptoren zijn onderdeel van het de G-proteïnegekoppelde receptoren en zijn betrokken bij verschillende fysiologische processen waaronder eetlust, de pijnzin, stemmingswisselingen en geheugenverlies. De lichaamseigen stof anandamide bindt zich aan de cannabinoïdereceptoren. Cannabinoïdereceptoren zijn door de binding met plantaardige cannabinoïden zoals tetrahydrocannabinol ook verantwoordelijk voor de impact van de psychoactieve effecten van cannabis. Men onderscheidt twee types cannabinoïdereceptoren; CB1 en CB2. Cannabinoidreceptor är G-proteinkopplade receptorer som tar emot och svarar på cannabinoider genom att skicka signaler till cellkärnan. Cannabinoiden hittar receptorerna via blodomloppet. Fram till 1988 var det fortfarande oklart huruvida cannabinoider framkallar sin effekt genom att påverka cellmembranen, liksom alkohol, eller genom att binda till en speciell sorts receptor. 1988 var året då man upptäckte cannabinoidreceptorn, och problemet var löst. De är vanliga i djur då man har funnit dem i däggdjur, fåglar, fiskar och reptiler. Man känner till två olika sorters cannabinoidreceptorer: CB1 och . Kanabinoidní receptory jsou receptory endokanabinoidního systému spřažené s G proteinem , které jsou zapojeny v řadě fyziologických procesů, včetně chuti, vnímání bolesti, nálady a paměti. Receptory jsou aktivovány třemi hlavními skupinami ligandů: endokanabinoidy z vlastní produkce savčích organismů,; rostlinné kanabinoidy (např. kanabidiol z konopí) a syntetické kanabinoidy (HU-210). Všechny endokanabinoidy a rostlinné kanabinoidy jsou lipofilní, v tuku rozpustné sloučeniny. I recettori cannabinoidi sono una classe di recettori della famiglia dei recettori accoppiati alla proteina G.La stimolazione dei recettori cannabinoidi inibisce l'enzima adenilato-ciclasi e quindi la produzione di AMP ciclico. I loro ligandi sono i cannabinoidi: endocannabinoidi, cannabinoidi naturali e cannabinoidi di sintesi. Receptory kannabinoidowe – grupa receptorów sprzężonych z białkami G, których ligandy znane są jako kannabinoidy. Dotychczas poznano dobrze ich dwa typy: CB1 i CB2; prawdopodobne jest istnienie również innych typów. Są one częścią układu endokannabinoidowego. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system – a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids; plant cannabinoids (such as Tetrahydrocannabinol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic. Los receptores cannabinoides, localizados a través del cuerpo, son parte del sistema endocannabinoide, el cual está involucrado en una variedad de procesos fisiológicos incluyendo el apetito, la sensibilidad al dolor, el humor y la memoria. Канабіноїдні рецептори — клас клітинних рецепторів, що належать надродині G-білокспряжених мембранних рецепторів і зв'язуються з ендоканабіноїдними лігандами(анандамід і 2-арахідоноілгліцерол) і екзогенними лігандами (власне канабіноїдами і їх синтетичними аналогами). Каннабиноидные рецепторы — класс клеточных рецепторов, принадлежащих суперсемейству G-протеинсвязанных мембранных рецепторов. Каннабиноидные рецепторы имеют три типа лигандов: * эндоканнабиноиды (анандамид и 2-арахидоноилглицерин), образующиеся в основном в сосцевидных телах лимбической системы головного мозга; * фитоканнабиноиды (ТГК и некоторые другие соединения); * синтетические каннабиноиды (HU-210). Els receptors de cannabinoides són una classe de receptors de la membrana cel·lular acoblats o associats a proteïnes G. Els receptors de cannabinoides són activats per lligands, que estan compostos de lípids, coneguts col·lectivament com els cannabinoides. La distinció d'aquests lligands es pot fer separant els cannabinoides en dos tipus: cannabinoides endògens (endocannabinoides), que es generen naturalment dins del cos, i cannabinoides exògens, que s'introdueixen en el cos com el cànnabis o un compost sintètic relacionat. Os receptores canabinoides são receptores localizados em todo o corpo e fazem parte do sistema endocanabinoide. Esses são uma classe de receptores acoplados à proteína G e são ativados por substâncias conhecidas como canabinoides, que podem ser endógenas (endocanabinoides), derivadas da Cannabis ou de agonistas sintéticos. E são divididos em dois subtipos principais, o CB1 e CB2.
foaf:name: cannabinoid receptor 2 (macrophage) cannabinoid receptor 1 (brain)
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dcterms:subject: dbc:G_protein-coupled_receptors
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dbp:wikiPageUsesTemplate: dbt:G_protein-coupled_receptors dbt:Medcn dbt:MeshName dbt:Infobox_protein dbt:PDB dbt:Cannabis_sidebar dbt:Reflist dbt:Further dbt:Main dbt:Cannabinoidergics dbt:Short_description
dbo:thumbnail: n21:Cb1_cb2_structure.png?width=300
dbp:omim: 114610 605051
dbp:altsymbols: CNR
dbp:caption: NMR solution structure of a peptide mimetic of the fourth cytoplasmic loop of the CB1 cannabinoid receptor based on the coordinates.
dbp:symbol: CNR1 CNR2
dbp:uniprot: P34972 P21554
dbo:abstract: Cannabinoidreceptor är G-proteinkopplade receptorer som tar emot och svarar på cannabinoider genom att skicka signaler till cellkärnan. Cannabinoiden hittar receptorerna via blodomloppet. Fram till 1988 var det fortfarande oklart huruvida cannabinoider framkallar sin effekt genom att påverka cellmembranen, liksom alkohol, eller genom att binda till en speciell sorts receptor. 1988 var året då man upptäckte cannabinoidreceptorn, och problemet var löst. De är vanliga i djur då man har funnit dem i däggdjur, fåglar, fiskar och reptiler. Man känner till två olika sorters cannabinoidreceptorer: CB1 och . Receptorer av typen CB1 hittar man främst i hjärnan, närmare bestämt på neuroner (nervceller) som ligger i det limbiska systemet (känslor, minneshantering) och i två delar som är av betydelse för rörelser; substantia nigra samt lillhjärnan. Man finner dem även i såväl manliga som kvinnliga fortplantningsystem. Receptorer av typen CB1 är i princip frånvarande i förlängda märgen (medulla oblongata), den del av hjärnan som ansvarar för de respiratoriska och kardiovaskulära funktionerna. Därför finns heller ingen risk för att respiratoriska eller hjärt- och kärlsystemet ska fallera, vilket det finns med många andra droger. CB1-receptorer verkar vara ansvariga för cannabisplantans euforiska och antikonvulsiva effekter. CB2-receptorer finner man enbart i immunsystemet, med störst koncentrationer i mjälten. Denna typ av cannabinoidreceptor verkar vara ansvarig för cannabisplantans antiinflammatoriska effekter, möjligen även andra terapeutiska effekter. Proteinsekvenserna i dessa två receptortyper är lika till ungefär 45 %. Små variationer i varje receptortyp har identifierats. Det finns vissa indikationer på att även andra receptortyper existerar, men inga har bekräftats. Cannabinoider binder reversibelt och stereoselektivt till cannabinoidreceptorerna. Cannabinoider som binder mer selektivt till vissa receptorer är att föredra för medicinskt bruk. Cannabinoider är generellt sett cannabinoidreceptoragonister, vilket betyder att de dockar med en cannabiniodreceptor och aktiverar den. Det har även forskats kring kemiska föreningar som förhindrar aktiveringen av receptorn. Sådana receptorantagonister har medicinsk potential. مستقبل الكانابينويد هو عضو من عائلة مستقبل مقترن بالبروتين ج ، أو المستقبل السباعي عبر الغشاء.و تم اكتشاف نوعين من من مستقبلات الكانابيويد ، مستقبل كانابينويد من النوع الأول (CB1) و مستقبل كانابينويد من النوع الثاني (CB2) و مستقبلات الكانابينويد هذه يتم تفعليها عن طريق ارتباطها بأحد الجزيئات الحيوية التالية : * الكانابينويد الداخلي أو الإندوكانابينويد * الكانابينويد التَخْليقِيّ * الكانابينويد النباتي (ينتج من نبات قنب هندي) Os receptores canabinoides são receptores localizados em todo o corpo e fazem parte do sistema endocanabinoide. Esses são uma classe de receptores acoplados à proteína G e são ativados por substâncias conhecidas como canabinoides, que podem ser endógenas (endocanabinoides), derivadas da Cannabis ou de agonistas sintéticos. E são divididos em dois subtipos principais, o CB1 e CB2. O CB1 se encontra predominantemente no sistema nervoso central, assim como nos pulmões, no fígado e nos rins. Já o receptor CB2 é expresso principalmente no sistema imunológico e em células hematopoiéticas; porém, novas pesquisas também encontraram esses receptores em partes do cérebro. Los receptores cannabinoides, localizados a través del cuerpo, son parte del sistema endocannabinoide, el cual está involucrado en una variedad de procesos fisiológicos incluyendo el apetito, la sensibilidad al dolor, el humor y la memoria. Los receptores cannabinoides son una clase de receptor de membrana celular bajo la familia de receptores acoplados a proteínas G, con sus característicos siete dominios transmembrana.Los receptores cannabinoides se activan por tres grupos principales de ligandos y endocannabinoides producidos por el cuerpo mamilar; cannabinoides de plantas (como el cannabidiol producido por la planta de cannabis) y cannabinoides sintéticos (como ). Todos los endocannabinoides y los cannabinoides de la planta son lipofílicos, es decir, son solubles en grasas. Actualmente hay dos subtipos de receptores cannabinoides, nombrados CB1 y CB2. El receptor CB1 se expresa principalmente en el (sistema nervioso central o "SNC") pero también en los pulmones, hígado y riñones. El receptor CB2 se expresa principalmente en el sistema inmune y en células hematopoiéticas. Evidencia sugiere que hay receptores cannabinoides novel que no son, CB1 ni CB2, los cuales están expresados en células endoteliales y en SNC. En 2007, los cannabinoides que se unen al receptor acoplado de proteína G en el cerebro fueron descritos. La secuencia de proteínas de los receptores CB1 y CB2 son cerca del 44% parecidas. Cuando solo se consideran las regiones transmembranales de los receptores, la similitud de aminoácidos entre las dos subtipos de receptores es aproximadamente 68%. Además, variaciones menores en cada receptor han sido identificadas. Los cannabinoides se unen de manera reversible y son estereoselectivos al receptor cannabinoide. Los cannabinoides de subtipo selectivo han sido desarrollados pues –teóricamente– pueden tener ventajas para los tratamientos de enfermedades como la obesidad. I recettori cannabinoidi sono una classe di recettori della famiglia dei recettori accoppiati alla proteina G.La stimolazione dei recettori cannabinoidi inibisce l'enzima adenilato-ciclasi e quindi la produzione di AMP ciclico. I loro ligandi sono i cannabinoidi: endocannabinoidi, cannabinoidi naturali e cannabinoidi di sintesi. Cannabinoïdereceptoren zijn onderdeel van het de G-proteïnegekoppelde receptoren en zijn betrokken bij verschillende fysiologische processen waaronder eetlust, de pijnzin, stemmingswisselingen en geheugenverlies. De lichaamseigen stof anandamide bindt zich aan de cannabinoïdereceptoren. Cannabinoïdereceptoren zijn door de binding met plantaardige cannabinoïden zoals tetrahydrocannabinol ook verantwoordelijk voor de impact van de psychoactieve effecten van cannabis. De receptoren werden ontdekt door het onderzoek naar de farmacologie van cannabis in het lichaam. Pas na het ontdekken van deze receptoren kwam men door verder onderzoek achter het bestaan en de werking van de neurotransmittor anandamide. Men onderscheidt twee types cannabinoïdereceptoren; CB1 en CB2. Каннабиноидные рецепторы — класс клеточных рецепторов, принадлежащих суперсемейству G-протеинсвязанных мембранных рецепторов. Каннабиноидные рецепторы имеют три типа лигандов: * эндоканнабиноиды (анандамид и 2-арахидоноилглицерин), образующиеся в основном в сосцевидных телах лимбической системы головного мозга; * фитоканнабиноиды (ТГК и некоторые другие соединения); * синтетические каннабиноиды (HU-210). Receptory kannabinoidowe – grupa receptorów sprzężonych z białkami G, których ligandy znane są jako kannabinoidy. Dotychczas poznano dobrze ich dwa typy: CB1 i CB2; prawdopodobne jest istnienie również innych typów. Są one częścią układu endokannabinoidowego. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system – a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids; plant cannabinoids (such as Tetrahydrocannabinol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic. There are two known subtypes of cannabinoid receptors, termed CB1 and CB2. The CB1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system, in hematopoietic cells, and in parts of the brain.\ The protein sequences of CB1 and CB2 receptors are about 44% similar. When only the transmembrane regions of the receptors are considered, amino acid similarity between the two receptor subtypes is approximately 68%. In addition, minor variations in each receptor have been identified. Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. Subtype selective cannabinoids have been developed which theoretically may have advantages for treatment of certain diseases such as obesity. Enzymes involved in biosynthesis/inactivation of endocannabinoids and endocannabinoid signaling in general (involving targets other than CB1/2-type receptors) occur throughout the animal kingdom. Канабіноїдні рецептори — клас клітинних рецепторів, що належать надродині G-білокспряжених мембранних рецепторів і зв'язуються з ендоканабіноїдними лігандами(анандамід і 2-арахідоноілгліцерол) і екзогенними лігандами (власне канабіноїдами і їх синтетичними аналогами). Kanabinoidní receptory jsou receptory endokanabinoidního systému spřažené s G proteinem , které jsou zapojeny v řadě fyziologických procesů, včetně chuti, vnímání bolesti, nálady a paměti. Receptory jsou aktivovány třemi hlavními skupinami ligandů: endokanabinoidy z vlastní produkce savčích organismů,; rostlinné kanabinoidy (např. kanabidiol z konopí) a syntetické kanabinoidy (HU-210). Všechny endokanabinoidy a rostlinné kanabinoidy jsou lipofilní, v tuku rozpustné sloučeniny. V současné době[kdy?] jsou známy dva podtypy kanabinoidních receptorů, označované jako CB -1 a CB -2. CB1 receptor je exprimován hlavně v mozku (centrální nervové soustavy nebo „CNS“), ale také v plicích, játrech a ledvinách. CB2 receptor je exprimován především v imunitním systému a v krvetvorných buňkách. Možná budou potvrzeny i nové kanabinoidní receptory ne CB1 a ne CB2, které jsou tvořeny v endoteliálních buňkách a v CNS. Das Endocannabinoid-System (Abk. für endogenes Cannabinoid-System) ist ein Teil des Nervensystems und umfasst die Cannabinoid-Rezeptoren CB1 und CB2 mit ihren natürlichen Liganden und der nachgeschalteten intrazellulären Signaltransduktion nach der Ligandenbindung in Vertebraten. Els receptors de cannabinoides són una classe de receptors de la membrana cel·lular acoblats o associats a proteïnes G. Els receptors de cannabinoides són activats per lligands, que estan compostos de lípids, coneguts col·lectivament com els cannabinoides. La distinció d'aquests lligands es pot fer separant els cannabinoides en dos tipus: cannabinoides endògens (endocannabinoides), que es generen naturalment dins del cos, i cannabinoides exògens, que s'introdueixen en el cos com el cànnabis o un compost sintètic relacionat. El cos humà posseeix llocs específics d'acoblament per als cannabinoides a la superfície de molts tipus de cèl·lules i el nostre organisme produeix diversos derivats d'àcids grassos, que s'acoblen a aquests receptors de cannabinoides (CB), activant-los. Junts, receptors CB i endocannabinoides, constitueixen el . Fins a la data d'avui, s'han identificat dos tipus de receptors de cannabinoides, els CB1 i els CB2. Es diferencien en el mode de transmetre el senyal i en la seva distribució en els diferents teixits. L'activació dels receptors cannabinoides dona lloc a una inhibició de l'adenil ciclasa, el qual impedeix la conversió de L'ATP a AMP cíclic (AMPc). També s'han observat altres, com per exemple la interacció amb certs canals d'ions. Ambdós, el CB1 i el CB2, pertanyen a l'extensa família de receptors acoblats a una proteïna G (G-proteincoupled receptors, GPCR). Són els més comuns, existint-ne de 1.000 a 2.000 en els vertebrats. El receptor CB1 s'expressa principalment en el cervell (sistema nerviós central, CNS), però també en els pulmons, el fetge i els ronyons. El receptor CB2 s'expressa principalment en el sistema immunològic i en les cèl·lules hematopoètiques. La creixent evidència suggereix que hi ha nous receptors cannabinoides, és a dir, no-CB 1 i no 2-CB, que estan expressats en les cèl·lules endotelials i en el SNC. El 2007 va ser descrita la unió de diversos cannabinoides als receptor acoblats a proteïnes G (GPCR) en el cervell. Les seqüències de proteïnes dels receptors CB1 i CB2 són un 44% similars, aproximadament. A més, han estat identificades petites variacions en cada un dels receptors. Els cannabinoides s'uneixen de forma reversible i estèreo-selectivament als receptors de cannabinoides. L'afinitat d'un cannabinoide individual a cada receptor determina l'efecte d'aquest cannabinoide. Els cannabinoides que s'uneixen de manera més selectiva a certs receptors són més convenients per a l'ús mèdic.
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