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Statements

Subject Item: dbr:Electron-capture_dissociation
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Metal-coded_affinity_tag
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Metaproteomics
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Mass_spectrometry
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Protein_mass_spectrometry
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Proteomics
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Overlapping_gene
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Bottom-up_proteomics
rdf:type: dbo:Software
rdfs:label: Bottom-up proteomics
rdfs:comment: Bottom-up proteomics is a common method to identify proteins and characterize their amino acid sequences and post-translational modifications by proteolytic digestion of proteins prior to analysis by mass spectrometry. The major alternative workflow used in proteomics is called top-down proteomics where intact proteins are purified prior to digestion and/or fragmentation either within the mass spectrometer or by 2D electrophoresis. Essentially, bottom-up proteomics is a relatively simple and reliable means of determining the protein make-up of a given sample of cells, tissues, etc.
dcterms:subject: dbc:Proteomics dbc:Mass_spectrometry
dbo:wikiPageID: 13688008
dbo:wikiPageRevisionID: 1099578651
dbo:wikiPageWikiLink: dbr:Proteolysis dbc:Mass_spectrometry dbr:Top-down_proteomics dbr:Tandem_mass_spectrometry dbr:Shotgun_proteomics n11:Top-down_vs_bottom-up_proteomics_image.tif dbr:Peptide_Spectral_Library dbr:Proteomics dbr:High_performance_liquid_chromatography dbr:Mass_spectrometry dbr:Protein_mass_spectrometry dbr:Post-translational_modification dbc:Proteomics
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dbo:abstract: Bottom-up proteomics is a common method to identify proteins and characterize their amino acid sequences and post-translational modifications by proteolytic digestion of proteins prior to analysis by mass spectrometry. The major alternative workflow used in proteomics is called top-down proteomics where intact proteins are purified prior to digestion and/or fragmentation either within the mass spectrometer or by 2D electrophoresis. Essentially, bottom-up proteomics is a relatively simple and reliable means of determining the protein make-up of a given sample of cells, tissues, etc. In bottom-up proteomics, the crude protein extract is enzymatically digested, followed by one or more dimensions of separation of the peptides by liquid chromatography coupled to mass spectrometry, a technique known as shotgun proteomics. By comparing the masses of the proteolytic peptides or their tandem mass spectra with those predicted from a sequence database or annotated peptide spectral in a peptide spectral library, peptides can be identified and multiple peptide identifications assembled into a protein identification.
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prov:wasDerivedFrom: wikipedia-en:Bottom-up_proteomics?oldid=1099578651&ns=0
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foaf:isPrimaryTopicOf: wikipedia-en:Bottom-up_proteomics

Subject Item: dbr:Leslie_M._Hicks
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Tandem_mass_spectrometry
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Liquid_chromatography–mass_spectrometry
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Isobaric_labeling
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Peptide_mass_fingerprinting
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Bottom-up
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics
dbo:wikiPageDisambiguates: dbr:Bottom-up_proteomics

Subject Item: dbr:Top-down_proteomics
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Citrullination
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Lys-N
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Venomics
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: dbr:Shotgun_proteomics
dbo:wikiPageWikiLink: dbr:Bottom-up_proteomics

Subject Item: wikipedia-en:Bottom-up_proteomics
foaf:primaryTopic: dbr:Bottom-up_proteomics