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Statements

Subject Item
dbr:Avian_HBV_RNA_encapsidation_signal_epsilon
rdf:type
dbo:Building yago:Abstraction100002137 yago:Part105867413 yago:PsychologicalFeature100023100 yago:Content105809192 yago:WikicatCis-regulatoryRNAElements yago:Idea105833840 yago:Concept105835747 yago:Cognition100023271 yago:Component105868954
rdfs:label
Avian HBV RNA encapsidation signal epsilon
rdfs:comment
The Avian HBV RNA encapsidation signal epsilon (AHBV epsilon) is an RNA structure that is shown to facilitate encapsidation of the required for viral replication. There are two main classes of encapsidation signals in avian hepatitis B viruses - Duck hepatitis B virus (DHBV) and Heron hepatitis B virus (HHBV) like. DHBV is used as a model to understand human Hepatitis B virus. Although studies have shown that the HHBV epsilon has less pairing in the upper stem than DHBV, this pairing is not absolutely required for DHBV infection in ducks.
dbp:name
AHBV_epsilon cis-regulatory RNA element Avian HBV RNA encapsidation signal epsilon
foaf:depiction
n6:DHBV_epsilon.png n6:HHBV_epsilon.jpg n6:AHBV_epsilon.jpg
dcterms:subject
dbc:Hepadnaviridae dbc:Cis-regulatory_RNA_elements
dbo:wikiPageID
19325688
dbo:wikiPageRevisionID
1122800621
dbo:wikiPageWikiLink
dbr:Rfam dbr:Cis-regulatory_element dbr:Pregenomic_RNA dbr:Hepatitis_B_virus dbr:Encapsidation dbr:Covariation_model dbr:Mutagenesis dbr:Secondary_structure dbr:Viral_replication dbr:Heron_hepatitis_B_virus n15:HHBV_epsilon.jpg dbr:Tetraloop n15:DHBV_epsilon.png dbr:RNA_structure dbr:Stem_loop dbc:Hepadnaviridae dbr:Sequence_conservation dbc:Cis-regulatory_RNA_elements dbr:Nucleic_acid_secondary_structure dbr:Duck_hepatitis_B_virus dbr:NMR_spectroscopy dbr:Avian_hepatitis_B_virus dbr:Virus dbr:HBV_RNA_encapsidation_signal_epsilon
owl:sameAs
yago-res:Avian_HBV_RNA_encapsidation_signal_epsilon n14:4UKGU freebase:m.04lj191 wikidata:Q4828546
dbp:taxDomain
Viruses
dbp:wikiPageUsesTemplate
dbt:GO dbt:Rfam dbt:Infobox_rfam dbt:SO dbt:Reflist dbt:Short_description dbt:Molecular-cell-biology-stub dbt:Cn
dbo:thumbnail
n6:DHBV_epsilon.png?width=300
dbp:caption
Predicted secondary structure and sequence conservation of AHBV_epsilon
dbp:id
RF01313
dbp:symbol
AHBV_epsilon
dbo:abstract
The Avian HBV RNA encapsidation signal epsilon (AHBV epsilon) is an RNA structure that is shown to facilitate encapsidation of the required for viral replication. There are two main classes of encapsidation signals in avian hepatitis B viruses - Duck hepatitis B virus (DHBV) and Heron hepatitis B virus (HHBV) like. DHBV is used as a model to understand human Hepatitis B virus. Although studies have shown that the HHBV epsilon has less pairing in the upper stem than DHBV, this pairing is not absolutely required for DHBV infection in ducks. DHBV epsilon consists of a stem structure, a bulge and an apical loop (Fig. 1). The RNA structure was determined by chemical probing, NMR analysis and by mutagenesis. HHBV epsilon also consists of a stem structure, a bulge and an apical loop (Fig. 2). The RNA structure has been determined by chemical probing and by mutagenesis. However, it has less base pairing in the upper stem than DHBV epsilon. Recent NMR analysis of both the HHBV and DHBV epsilon have shown that the apical loop to be capped by a stable well-structured UGUU tetraloop. In the Rfam database a single covariation model (AHBV_epsilon box right) best discriminates between the true instances of the element in sequence databases and background. The secondary structure diagram is a computer generated view of the structure with highly conserved bases shown in red. It includes the major elements shown in Figures 1 and 2.
dbp:rfam
RF01313
dbp:rnaType
dbr:Cis-regulatory_element
gold:hypernym
dbr:Structure
prov:wasDerivedFrom
wikipedia-en:Avian_HBV_RNA_encapsidation_signal_epsilon?oldid=1122800621&ns=0
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4312
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wikipedia-en:Avian_HBV_RNA_encapsidation_signal_epsilon
Subject Item
dbr:HHBV_epsilon
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dbr:Avian_HBV_RNA_encapsidation_signal_epsilon
dbo:wikiPageRedirects
dbr:Avian_HBV_RNA_encapsidation_signal_epsilon
Subject Item
dbr:Duck_HBV_RNA_encapsidation_signal_epsilon
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dbr:Avian_HBV_RNA_encapsidation_signal_epsilon
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dbr:Avian_HBV_RNA_encapsidation_signal_epsilon
Subject Item
dbr:Heron_HBV_RNA_encapsidation_signal_epsilon
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dbr:Avian_HBV_RNA_encapsidation_signal_epsilon
dbo:wikiPageRedirects
dbr:Avian_HBV_RNA_encapsidation_signal_epsilon
Subject Item
wikipedia-en:Avian_HBV_RNA_encapsidation_signal_epsilon
foaf:primaryTopic
dbr:Avian_HBV_RNA_encapsidation_signal_epsilon