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rdfs:label: 자가면역성용혈성빈혈 فقر الدم الانحلالي بالمناعة الذاتية 自己免疫性溶血性貧血 Auto-immuun hemolytische anemie Autoimmune hemolytic anemia Anemia hemolítica autoimune Anemia emolitica autoimmune Anèmia hemolítica autoimmunitària Иммуногемолитические анемии Autoimmunhämolytische Anämie Autoimmun hemolytisk anemi Anemia hemolítica autoinmune
rdfs:comment: Una anèmia hemolítica autoimmunitària (AHAI) és un tipus d'anèmia hemolítica on el sistema immunològic del cos ataca els seus propis glòbuls vermells, fenomen que condueix a la seva destrucció (hemòlisi), la qual pot ser intravascular o extravascular. 狭義の自己免疫性溶血性貧血（じこめんえきせいひんけつ、autoimmune hemolytic anemia; AIHA）とは、温式抗体に属する自己抗体により赤血球が感作され、溶血をきたす疾患である。広義には寒冷凝集素が関与するやドナース・ランドスタイナー抗体（Donath-Landsteiner antibody）に伴うなどの比較的稀な病態も含めることもある。さらに各種薬剤に起因するを合わせて免疫介在性溶血性貧血と称することもある。本項では特にことわりのない限り、ヒトにおける狭義の自己免疫性溶血性貧血について解説する。 Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in serious cases. The intracellular components of the RBCs are released into the circulating blood and into tissues, leading to some of the characteristic symptoms of this condition. The antibodies are usually directed against high-incidence antigens, therefore they also commonly act on allogenic RBCs (RBCs originating from outside the person themselves, e.g. in the case of a blood transfusion). AIHA is a relatively rare condition, with an incidence of 5-10 cases per 1 million pe Auto-immuun hemolytische anemie (AIHA) is een hemolytische anemie veroorzaakt door het eigen immuunsysteem (auto-immuun). Bij AIHA worden de rode bloedcellen overmatig snel afgebroken (sneller dan het beenmerg de bloedcellen kan produceren, waardoor bloedarmoede ontstaat), onder invloed van antistoffen die actief zijn bij de lichaamstemperatuur of lagere temperaturen. Men maakt het volgende onderscheid: L'anemia emolitica autoimmune (o autoimmune haemolytic anaemia; AIHA) insorge quando anticorpi diretti contro gli eritrociti (RBCs) ne causano la lisi, ciò porta a una concentrazione insufficiente di emazie (eritrociti) nel plasma.La vita dei globuli rossi (eritrociti) si riduce dai normali 100-120 giorni a, in casi gravi, solamente pochi giorni. I componenti intracellulari degli eritrociti vengono rilasciati nel sangue circolante e nei tessuti, causando alcuni dei sintomi caratteristici di questa condizione. Gli anticorpi sono solitamente diretti contro antigeni ad alta incidenza, possono dunque reagire comunemente contro eritrociti allogenici (RBCs provenienti dall'esterno della persona stessa, per esempio in caso di una trasfusione di sangue) L'anemia emolitica autoimmune è una condizio Las anemias hemolítica autoinmune son un grupo de anemias hemolíticas poco frecuentes, causadas por enfermedades autoinmunes en donde el sistema inmune ataca a los glóbulos rojos. La hemólisis puede ser intravascular (mediada por complemento) o extravascular (en el sistema fagocítico mononuclear por inmunidad celular). También se llama anemia hemolítica inmunocompleja. Eine autoimmunhämolytische Anämie (abgekürzt AIHA) ist eine erworbene hämolytische Anämie, die durch Autoantikörper, d. h. durch Antikörper, die gegen eigene Antigene gerichtet sind, verursacht wird. Diese Antikörper heften sich an die Erythrozyten (roten Blutzellen) und können unter bestimmten Umständen zu deren Zerstörung (Hämolyse) führen. Die autoimmunhämolytischen Anämien sind erworbene, nicht ansteckende Erkrankungen. Autoimmun hemolytisk anemi är en form av brist på röda blodkroppar som orsakas av att kroppens egna immunförsvar angriper och förstör dem. A anemia hemolítica auto-imune ou anemia mediada imunologicamente é um tipo de anemia hemolítica e divide-se em em dois tipos principais, a anemia hemolítica de anticorpos reativos ao frio e a anemia hemolítica de anticorpos reativos ao calor, sendo esta a mais comum. Иммуногемолитические анемии — группа анемий, относящихся к иммунозависимым экзоэритроцитарным гемолитическим анемиям. Этиология данных анемий связана с индукцией аутоаллергии к собственным эритроцитарным антигенам, иммунным ответом на гаптены и антигены адсорбируемые эритроцитами, иммунокомплексными реакциями, либо с аллоиммунизацией. Эритроциты больных при иммунном гемолизе разрушаются: 1. Вследствие связывания их нативных антигенов с антителами и, в последующем — компонентами комплемента, осуществляющими прямой цитолиз — аутоиммунный комплемент-зависимый гемолиз. 자가면역성용혈성빈혈(自家免疫性溶血性貧血, autoimmune hemolytic anemia, autoimmune haemolytic anaemia, AIHA)은 인체의 적혈구에 대항하는 항체가 생성되어 용혈을 일으키면서 용혈성 빈혈이 발생하는 질병이다. فقر الدم الانحلالي الناجم عن المناعة الذاتية (أو ). يحدث عندما تقوم الأجسام المضادة بمهاجمة خلايا الدم الحمراء (كرات الدم الحمراء) الخاصة بالشخص نفسه لتسبب لها انفجار (تحلل)، مما يؤدي إلى نقص كريات الدم الحمراء في الدورة الدموية إلى مستوى غير كافِ. ويقل يقل عمر كرات الدم الحمراء من 100-120 يوم في الوضع الطبيعي إلى بضعة أيام فقط في الحالات الخطيرة .يتم اطلاق مكونات الخلايا من كرات الدم الحمراء إلى الدورة الدموية والأنسجة مما يؤدي إلى بعض الأعراض المميزة لهذه الحالة.
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dbp:synonyms: Autoimmune haemolytic anaemia
dbo:abstract: 狭義の自己免疫性溶血性貧血（じこめんえきせいひんけつ、autoimmune hemolytic anemia; AIHA）とは、温式抗体に属する自己抗体により赤血球が感作され、溶血をきたす疾患である。広義には寒冷凝集素が関与するやドナース・ランドスタイナー抗体（Donath-Landsteiner antibody）に伴うなどの比較的稀な病態も含めることもある。さらに各種薬剤に起因するを合わせて免疫介在性溶血性貧血と称することもある。本項では特にことわりのない限り、ヒトにおける狭義の自己免疫性溶血性貧血について解説する。 Иммуногемолитические анемии — группа анемий, относящихся к иммунозависимым экзоэритроцитарным гемолитическим анемиям. Этиология данных анемий связана с индукцией аутоаллергии к собственным эритроцитарным антигенам, иммунным ответом на гаптены и антигены адсорбируемые эритроцитами, иммунокомплексными реакциями, либо с аллоиммунизацией. Эритроциты больных при иммунном гемолизе разрушаются: 1. Вследствие связывания их нативных антигенов с антителами и, в последующем — компонентами комплемента, осуществляющими прямой цитолиз — аутоиммунный комплемент-зависимый гемолиз. 2. По аналогичному механизму с опсонизирующим действием аутоантител и распадом фагоцитированных эритроцитов — аутоиммунный внутриклеточный гемолиз 3. Вследствие адсорбции иммунных комплексов с участием неэритроцитарных антигенов и последующего комплемент-зависимого лизиса — «механизм невинного свидетеля» Eine autoimmunhämolytische Anämie (abgekürzt AIHA) ist eine erworbene hämolytische Anämie, die durch Autoantikörper, d. h. durch Antikörper, die gegen eigene Antigene gerichtet sind, verursacht wird. Diese Antikörper heften sich an die Erythrozyten (roten Blutzellen) und können unter bestimmten Umständen zu deren Zerstörung (Hämolyse) führen. Die autoimmunhämolytischen Anämien sind erworbene, nicht ansteckende Erkrankungen. L'anemia emolitica autoimmune (o autoimmune haemolytic anaemia; AIHA) insorge quando anticorpi diretti contro gli eritrociti (RBCs) ne causano la lisi, ciò porta a una concentrazione insufficiente di emazie (eritrociti) nel plasma.La vita dei globuli rossi (eritrociti) si riduce dai normali 100-120 giorni a, in casi gravi, solamente pochi giorni. I componenti intracellulari degli eritrociti vengono rilasciati nel sangue circolante e nei tessuti, causando alcuni dei sintomi caratteristici di questa condizione. Gli anticorpi sono solitamente diretti contro antigeni ad alta incidenza, possono dunque reagire comunemente contro eritrociti allogenici (RBCs provenienti dall'esterno della persona stessa, per esempio in caso di una trasfusione di sangue) L'anemia emolitica autoimmune è una condizione relativamente rara, che colpisce 1-3 individui su 100.000 per anno. Las anemias hemolítica autoinmune son un grupo de anemias hemolíticas poco frecuentes, causadas por enfermedades autoinmunes en donde el sistema inmune ataca a los glóbulos rojos. La hemólisis puede ser intravascular (mediada por complemento) o extravascular (en el sistema fagocítico mononuclear por inmunidad celular). También se llama anemia hemolítica inmunocompleja. A anemia hemolítica auto-imune ou anemia mediada imunologicamente é um tipo de anemia hemolítica e divide-se em em dois tipos principais, a anemia hemolítica de anticorpos reativos ao frio e a anemia hemolítica de anticorpos reativos ao calor, sendo esta a mais comum. Autoimmun hemolytisk anemi är en form av brist på röda blodkroppar som orsakas av att kroppens egna immunförsvar angriper och förstör dem. Una anèmia hemolítica autoimmunitària (AHAI) és un tipus d'anèmia hemolítica on el sistema immunològic del cos ataca els seus propis glòbuls vermells, fenomen que condueix a la seva destrucció (hemòlisi), la qual pot ser intravascular o extravascular. Auto-immuun hemolytische anemie (AIHA) is een hemolytische anemie veroorzaakt door het eigen immuunsysteem (auto-immuun). Bij AIHA worden de rode bloedcellen overmatig snel afgebroken (sneller dan het beenmerg de bloedcellen kan produceren, waardoor bloedarmoede ontstaat), onder invloed van antistoffen die actief zijn bij de lichaamstemperatuur of lagere temperaturen. Men maakt het volgende onderscheid: Warme-antistoffenrode bloedcellen worden afgebroken in de milt bij lichaamstemperatuur onder invloed van immunoglobuline G, vaak is hierbij sprake van splenomegalie.Koude-antistoffenrode bloedcellen worden afgebroken in de aderen bij temperaturen lager dan de lichaamstemperatuur (vaak tot ongeveer 30°C) onder invloed van immunoglobuline M of soms immunoglobuline A. 자가면역성용혈성빈혈(自家免疫性溶血性貧血, autoimmune hemolytic anemia, autoimmune haemolytic anaemia, AIHA)은 인체의 적혈구에 대항하는 항체가 생성되어 용혈을 일으키면서 용혈성 빈혈이 발생하는 질병이다. Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in serious cases. The intracellular components of the RBCs are released into the circulating blood and into tissues, leading to some of the characteristic symptoms of this condition. The antibodies are usually directed against high-incidence antigens, therefore they also commonly act on allogenic RBCs (RBCs originating from outside the person themselves, e.g. in the case of a blood transfusion). AIHA is a relatively rare condition, with an incidence of 5-10 cases per 1 million persons per year in the warm-antibody type and 0.45 to 1.9 cases per 1 million persons per year in the cold antibody type. Autoimmune hemolysis might be a precursor of later onset systemic lupus erythematosus. The terminology used in this disease is somewhat ambiguous. Although MeSH uses the term "autoimmune hemolytic anemia", some sources prefer the term "immunohemolytic anemia" so drug reactions can be included in this category. The National Cancer Institute considers "immunohemolytic anemia", "autoimmune hemolytic anemia", and "immune complex hemolytic anemia" to all be synonyms. فقر الدم الانحلالي الناجم عن المناعة الذاتية (أو ). يحدث عندما تقوم الأجسام المضادة بمهاجمة خلايا الدم الحمراء (كرات الدم الحمراء) الخاصة بالشخص نفسه لتسبب لها انفجار (تحلل)، مما يؤدي إلى نقص كريات الدم الحمراء في الدورة الدموية إلى مستوى غير كافِ. ويقل يقل عمر كرات الدم الحمراء من 100-120 يوم في الوضع الطبيعي إلى بضعة أيام فقط في الحالات الخطيرة .يتم اطلاق مكونات الخلايا من كرات الدم الحمراء إلى الدورة الدموية والأنسجة مما يؤدي إلى بعض الأعراض المميزة لهذه الحالة. توجه عادة الأجسام المضادة ضد مولدات الضد (الأنتجين)، وبالتالي تعمل أيضا ضد كرات الدم الحمراء القادمة من خارج الشخص نفسه، على سبيل المثال في حالة نقل الدم. ويعدّ فقر الدم الانحلالي حالة نادرة نسبيا تصيب واحد إلى ثلاثة أشخاص لكل 100000 شخص سنويا. تعدّ المصطلحات المستخدمة في هذا المرض غامضة بعض الشيء. على الرغم من أن نظام فهرسة المواضيع الطبية تستخدم المصطلح فقر الدم الانحلالي بالمناعة الذاتية، الا ان بعض المصادر يفضلون مصطلح «» وبالتالي يمكن أن تدرج التفاعلات الدوائية في هذه الفئة. المعهد الوطني للسرطان يعدّ «فقر الدم المناعي»، «فقر الدم الانحلالي الذاتي»، و «» كلها مرادفات.
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