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Statements

Subject Item
dbr:Acute_to_chronic_ratio
rdfs:label
Acute to chronic ratio
rdfs:comment
The acute to chronic ratio (ACR) uses acute toxicity data to gauge the chronic toxicity (MATC) of a chemical of interest to an organism. The science behind determining a safe concentration to the environment is imperfect, statistically limited, and resource intensive. There is an unfilled demand for the rapid assessment of different chemical toxicity to many different organisms. The ACR is a proposed solution to this demand.
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dbc:Toxicology
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53988133
dbo:wikiPageRevisionID
1108472765
dbo:wikiPageWikiLink
dbr:Acute_toxicity dbr:TSCA dbr:Toxicity dbr:EPA dbr:Maximum_acceptable_toxicant_concentration dbr:Chronic_toxicity dbr:LC50 dbr:No-observed-adverse-effect_level dbr:Quantitative_structure_activity_relationship dbc:Toxicology dbr:Chemical_structure dbr:Chemical_properties dbr:Maximum_Acceptable_Toxicant_Concentration
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dbo:abstract
The acute to chronic ratio (ACR) uses acute toxicity data to gauge the chronic toxicity (MATC) of a chemical of interest to an organism. The science behind determining a safe concentration to the environment is imperfect, statistically limited, and resource intensive. There is an unfilled demand for the rapid assessment of different chemical toxicity to many different organisms. The ACR is a proposed solution to this demand. While empirical methods are crucial to making scientific conclusions and informed decisions, best personal judgement is often the best tool to the regulator in allowing or prohibiting potentially toxic chemicals from entering the environment. This means taking into consideration information about chemical structure, physical and chemical properties including fate and transport in the environment, and most importantly toxicological data. The ACR is mathematically the inverse of the application factor (AF), which was first proposed by Mount and Stephan (1967). It provides no new information, it simply converts AF values into whole integer numbers that are more easily comparable for researchers visually.
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wikipedia-en:Acute_to_chronic_ratio?oldid=1108472765&ns=0
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wikipedia-en:Acute_to_chronic_ratio
Subject Item
dbr:Chronic_toxicity
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dbr:Acute_to_chronic_ratio
Subject Item
wikipedia-en:Acute_to_chronic_ratio
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dbr:Acute_to_chronic_ratio