William B. Derrick (July 27, 1843 – April 15, 1913) was an African Methodist Episcopal (AME) bishop and missionary. He worked as a seaman early in his life and served in the Union Navy during the US Civil War. After the war, he joined the AME church and became involved in church leadership and missionary activities. He became a bishop of the church in 1896. He was also involved in Republican politics and civil rights.