About: Cord factor

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly.

Property Value
dbo:abstract
  • Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly. (en)
  • El factor cuerda​ o dimicolato de trehalosa, es una molécula de glucolípido encontrada en la pared de célula de Mycobacterium tuberculosis y especie similar. Es el lípido primario encontrado en el exterior de las células de M. tuberculosis.​ El factor cuerda influye el arreglo de células de M. tuberculosis a formaciones largas y esbeltas, dando su nombre.​ Este factor es virulento hacia células mamíferos y crítico para supervivencia de M. tuberculosis en anfitriones, pero no exteriores de anfitriones.​​ El factor cuerda ha sido observado para influir respuestas inmunes, inducir la formación de granulomas, e inhibir crecimiento de tumor.​ El antimycobacterial fármaco SQ109 está pensado para inhibir TDM niveles de producción y de este modo interrumpe su asamblea de pared de la célula.​ (es)
dbo:thumbnail
dbo:wikiPageID
  • 18856487 (xsd:integer)
dbo:wikiPageLength
  • 31288 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1123407730 (xsd:integer)
dbo:wikiPageWikiLink
dbp:imagefile
  • Trehalose dimycolate.svg (en)
dbp:imagesize
  • 400 (xsd:integer)
dbp:verifiedfields
  • changed (en)
dbp:verifiedrevid
  • 428744589 (xsd:integer)
dbp:watchedfields
  • changed (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly. (en)
  • El factor cuerda​ o dimicolato de trehalosa, es una molécula de glucolípido encontrada en la pared de célula de Mycobacterium tuberculosis y especie similar. Es el lípido primario encontrado en el exterior de las células de M. tuberculosis.​ El factor cuerda influye el arreglo de células de M. tuberculosis a formaciones largas y esbeltas, dando su nombre.​ Este factor es virulento hacia células mamíferos y crítico para supervivencia de M. tuberculosis en anfitriones, pero no exteriores de anfitriones.​​ El factor cuerda ha sido observado para influir respuestas inmunes, inducir la formación de granulomas, e inhibir crecimiento de tumor.​ El antimycobacterial fármaco SQ109 está pensado para inhibir TDM niveles de producción y de este modo interrumpe su asamblea de pared de la célula.​ (es)
rdfs:label
  • Factor cuerda (es)
  • Cord factor (en)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License