An Entity of Type: protein, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene. TIGAR is a recently discovered enzyme that primarily functions as a regulator of glucose breakdown in human cells. In addition to its role in controlling glucose degradation, TIGAR activity can allow a cell to carry out DNA repair, and the degradation of its own organelles. Finally, TIGAR can protect a cell from death. Since its discovery in 2005 by Kuang-Yu Jen and Vivian G. Cheung, TIGAR has become of particular interest to the scientific community thanks to its active role in many cancers. Normally, TIGAR manufacture by the body is activated by the p53 tumour suppressor protein after a cell has experienced a low level o

Property Value
dbo:abstract
  • The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene. TIGAR is a recently discovered enzyme that primarily functions as a regulator of glucose breakdown in human cells. In addition to its role in controlling glucose degradation, TIGAR activity can allow a cell to carry out DNA repair, and the degradation of its own organelles. Finally, TIGAR can protect a cell from death. Since its discovery in 2005 by Kuang-Yu Jen and Vivian G. Cheung, TIGAR has become of particular interest to the scientific community thanks to its active role in many cancers. Normally, TIGAR manufacture by the body is activated by the p53 tumour suppressor protein after a cell has experienced a low level of DNA damage or stress. In some cancers, TIGAR has fallen under the control of other proteins. The hope is that future research into TIGAR will provide insight into new ways to treat cancer. This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. (en)
  • TIGAR (англ. TP53 induced glycolysis regulatory phosphatase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 270 амінокислот, а молекулярна маса — 30 063. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: Валін Y: Тирозин Кодований геном білок за функцією належить до гідролаз. Задіяний у таких біологічних процесах, як апоптоз, автофагія, ацетилювання. Локалізований у цитоплазмі, ядрі, мітохондрії. (uk)
dbo:thumbnail
dbo:wikiPageID
  • 38879444 (xsd:integer)
dbo:wikiPageLength
  • 28189 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1081700367 (xsd:integer)
dbo:wikiPageWikiLink
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene. TIGAR is a recently discovered enzyme that primarily functions as a regulator of glucose breakdown in human cells. In addition to its role in controlling glucose degradation, TIGAR activity can allow a cell to carry out DNA repair, and the degradation of its own organelles. Finally, TIGAR can protect a cell from death. Since its discovery in 2005 by Kuang-Yu Jen and Vivian G. Cheung, TIGAR has become of particular interest to the scientific community thanks to its active role in many cancers. Normally, TIGAR manufacture by the body is activated by the p53 tumour suppressor protein after a cell has experienced a low level o (en)
  • TIGAR (англ. TP53 induced glycolysis regulatory phosphatase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 270 амінокислот, а молекулярна маса — 30 063. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: Валін Y: Тирозин (uk)
rdfs:label
  • TP53-inducible glycolysis and apoptosis regulator (en)
  • TIGAR (uk)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License