In genetics, rs4680 (Val158Met) is a genetic variant.It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase.The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158. The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour. The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the SzGene database shows no or very little effect.
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