About: Rogletimide

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Rogletimide, also known as pyridoglutethimide, is a medication which was never marketed. It is related in chemical structure to the sedative/hypnotic drug glutethimide, but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and has no significant sedative-hypnotic effect. This makes it potentially useful in the treatment of breast cancer, and with fewer side effects than aminoglutethimide, but its lower potency caused it to be unsuccessful in clinical trials.

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dbo:abstract
  • Rogletimide, also known as pyridoglutethimide, is a medication which was never marketed. It is related in chemical structure to the sedative/hypnotic drug glutethimide, but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and has no significant sedative-hypnotic effect. This makes it potentially useful in the treatment of breast cancer, and with fewer side effects than aminoglutethimide, but its lower potency caused it to be unsuccessful in clinical trials. (en)
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  • 92788-10-8
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dbo:fdaUniiCode
  • 14P4QR28QF
dbo:pubchem
  • 56487
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  • 12 (xsd:integer)
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  • 92788 (xsd:integer)
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  • 50963 (xsd:integer)
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  • 14 (xsd:integer)
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  • 56487 (xsd:integer)
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dbp:smiles
  • O=C1NCCCC1CC (en)
dbp:synonyms
  • Roglethimide; Pyridoglutethimide (en)
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  • 14 (xsd:integer)
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  • 175 (xsd:integer)
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  • Rogletimide, also known as pyridoglutethimide, is a medication which was never marketed. It is related in chemical structure to the sedative/hypnotic drug glutethimide, but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and has no significant sedative-hypnotic effect. This makes it potentially useful in the treatment of breast cancer, and with fewer side effects than aminoglutethimide, but its lower potency caused it to be unsuccessful in clinical trials. (en)
rdfs:label
  • Rogletimide (en)
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